1695-P: On the Temporal Relationship between Telomere Length and Adiposity Levels

Short telomere length (TL) has been found to be associated with obesity related traits. However, most studies were cross-sectional in nature and conducted in adult subjects only. We aimed at examining the temporal relationship between telomere length and adiposity levels, measured by BMI, in both adults and youth. Our samples were selected from a population-based prospective cohort study in Southwest Amerindians who are at high risk for metabolic disorders. We obtained TL measures at 2 time points >10 years apart for 805 individuals who had concomitant BMI measures, and designated these as baseline and follow-up (f/u) exams; 1/3 were male and 1/3 were aged