1324-P: Mortality and Glycemic Control in Chronic Pancreatitis With and Without Diabetes—A Single Center, Referral Population Study in the United States

Introduction: To our knowledge, limited data are available regarding mortality and glycemic control in patients with chronic pancreatitis (CP) and diabetes mellitus (DM) in the United States. Methods: After IRB approval, we retrospectively studied 496 subjects with CP at Mayo Clinic, Rochester between 01/01/2013 and 12/31/2015. DM was identified using ICD 9 and 10 codes in 250 patients (CPDM cohort). Results: CPDM cohort had identified F/M 91/159 with median age of 56 yrs., BMI 24.2 kg/m2 and DM for 9.5 yrs. whereas CP without DM (CPWODM) cohort had F/M 106/140 with median age of 51 yrs. and BMI 26 kg/m2. In CPDM cohort, mean HbA1c was > 7 % from baseline to 5 yrs., hospitalizations due to any reason were highest within 1 yr. of DM diagnosis (Table). CP patients who developed DM had higher rates of 10 yr. mortality compared with those without DM (20.8% vs. 13.4%, Odd ratio 1.7, 95% CI=1.05-2.73, P= 0.03). Conclusion: Other studies outside the U.S have reported high mortality among CPDM subjects as compared to DM without CP. We report a unique comparison of mortality in CPDM vs. CPWODM in the U.S. CP patients who developed DM had 70% higher risk of 10-year mortality as compared to those who did not develop DM. Studies with larger sample size need to be conducted to confirm these findings. Clinical trials to improve diabetes in CP are warranted and could impact morbidity and mortality.