459-P: Remnant Cholesterol and the Presence of Coronary Artery Disease Are Mutually Independent Predictors for the Development of Type 2 Diabetes Mellitus

Remnant cholesterol is a predictor of cardiovascular event risk and is associated with the metabolic syndrome as well as with type 2 diabetes (T2DM). Whether this lipid parameter also predicts incident diabetes in subjects who do not yet have diabetes is less clear. We therefore prospectively recorded incident diabetes over 4 years in 864 consecutive nondiabetic Caucasian patients who underwent coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD). Diabetes was diagnosed according to ADA criteria. At baseline, 54.4% of our patients had significant CAD with lumen narrowing ≥50% at angiography; remnant cholesterol was significantly higher in patients with than in those without significant CAD (24±24 vs 19±18 mg/dl; p