Nutritional management of a patient with chronic intestinal failure and hemodialysis receiving teduglutide: A case report

•This case report assessed the use of teduglutide in a patient with short bowel syndrome undergoing hemodialysis.•A complete nutritional assessment was performed using bioelectrical impedance vector analysis.•Teduglutide treatment was successful after a 1-y follow-up.•A complete nutritional assessme...

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Veröffentlicht in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2023-09, Vol.113, p.112137, Article 112137
Hauptverfasser: Florencio Ojeda, Luna, Domínguez Rabadán, Rocío, Laínez López, María, Jaldón Hidalgo, Guadalupe, Rodríguez Andrés, Nuria, Penco Ramírez, Cinta, Rebollo Pérez, María Isabel
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Sprache:eng
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Zusammenfassung:•This case report assessed the use of teduglutide in a patient with short bowel syndrome undergoing hemodialysis.•A complete nutritional assessment was performed using bioelectrical impedance vector analysis.•Teduglutide treatment was successful after a 1-y follow-up.•A complete nutritional assessment including bioelectrical impedance vector analysis, blood tests, and anthropometry can be good practice for monitoring nutrition in patients with short bowel syndrome and chronic kidney disease requiring hemodialysis. We present the case of a 35-y-old woman with short bowel syndrome secondary to extensive intestinal resection with associated chronic kidney disease who was undergoing hemodialysis. This patient required permanent supplementation with intradialytic parenteral nutrition because of a high-output end-jejunostomy. The patient was a candidate for treatment with teduglutide, a glucagon-like peptide 2 analog, intending to increase intestinal absorption. A complete nutritional assessment was performed using bioelectrical impedance vector analysis. Teduglutide treatment was successful, and after a 1-y follow-up, the patient had considerably reduced end-jejunostomy output (reduction of 6 L/d) and an improved nutritional status (9.1 kg weight gain, 1.4 kg fat-free mass gain, and a 2.2-degree increase in bioimpedance phase angle). However, we have been unable to reduce intradialytic parenteral nutrition, which the patient requires thrice weekly. No significant secondary effects have occurred because of teduglutide administration. This may be the first reported use of teduglutide in a patient with short bowel syndrome undergoing hemodialysis who was monitored using bioelectrical impedance data during follow-up.
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2023.112137