Detection of squamous neoplasia by fluorescence imaging comparing porfimer sodium fluorescence to tissue autofluorescence in the hamster cheek-pouch model
Background: Early neoplastic changes in the oral cavity may be difficult to detect. Fluorescence imaging using porphyrin-derived drugs has been used to enhance detection of neoplasia. Autofluorescence has also been used for this purpose. This paper compares autofluorescence to porfimer sodium-induce...
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| Veröffentlicht in: | The American journal of surgery 1995-11, Vol.170 (5), p.423-426 |
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| creator | Pathak, Irvin Davis, Noelle L. Hsiang, York N. Quenville, Noel F. Palcic, Branko |
| description | Background: Early neoplastic changes in the oral cavity may be difficult to detect. Fluorescence imaging using porphyrin-derived drugs has been used to enhance detection of neoplasia. Autofluorescence has also been used for this purpose. This paper compares autofluorescence to porfimer sodium-induced fluorescence in the detection of neoplasia in the hamster cheek-pouch model.
Materials and methods: Neoplasia was induced in the hamster cheek pouch by the application of 9, 10-dimethyl-1,2-benzanthracene. Animals were imaged either with injection of drug (porfimer sodium) or without drug (autofluorescence). Imaging was carried out using a laser-induced fluorescence detection system. Biopies were performed on imaged sections and histologic grades were assigned.
Results: Porfimer sodium fluorescence provided 100% sensitivity and specificity in detection of neoplasia. The sensitivity and specificity with autofluorescence was 76% and 83%, respectively.
Conclusions: Autofluorescence provides an accurate means of detecting early neoplastic changes in the hamster cheek-pouch model; however, porfimer sodium imaging does improve detection rates. |
| doi_str_mv | 10.1016/S0002-9610(99)80321-3 |
| format | Article |
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Materials and methods: Neoplasia was induced in the hamster cheek pouch by the application of 9, 10-dimethyl-1,2-benzanthracene. Animals were imaged either with injection of drug (porfimer sodium) or without drug (autofluorescence). Imaging was carried out using a laser-induced fluorescence detection system. Biopies were performed on imaged sections and histologic grades were assigned.
Results: Porfimer sodium fluorescence provided 100% sensitivity and specificity in detection of neoplasia. The sensitivity and specificity with autofluorescence was 76% and 83%, respectively.
Conclusions: Autofluorescence provides an accurate means of detecting early neoplastic changes in the hamster cheek-pouch model; however, porfimer sodium imaging does improve detection rates.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/S0002-9610(99)80321-3</identifier><identifier>PMID: 7485724</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>1,2-Benzanthracene ; 9,10-Dimethyl-1,2-benzanthracene - adverse effects ; Animals ; Antineoplastic Agents ; Biological and medical sciences ; Biopsy ; Carcinogens - adverse effects ; Cheek pouch ; Cricetinae ; Disease Models, Animal ; Double-Blind Method ; Fluorescence ; Fluorescent Dyes ; Hematoporphyrin Derivative ; Imaging ; Laser induced fluorescence ; Lasers ; Male ; Medical sciences ; Mesocricetus ; Mouth Mucosa - drug effects ; Mouth Mucosa - pathology ; Mouth Neoplasms - chemically induced ; Mouth Neoplasms - pathology ; Neoplasms, Squamous Cell - chemically induced ; Neoplasms, Squamous Cell - pathology ; Oral cavity ; Otorhinolaryngology. Stomatology ; Porphyrins ; Precancerous Conditions - chemically induced ; Precancerous Conditions - pathology ; ROC Curve ; Sensitivity ; Sensitivity and Specificity ; Sodium ; Squamous cell carcinoma ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>The American journal of surgery, 1995-11, Vol.170 (5), p.423-426</ispartof><rights>1995 Excerpta Medica, Inc. All rights reserved.</rights><rights>1996 INIST-CNRS</rights><rights>1995. Excerpta Medica, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-2869654e2e58c5bf34a1a2aa8da62b8691d8674e89a13d1a58e8b26cb253c2a13</citedby><cites>FETCH-LOGICAL-c417t-2869654e2e58c5bf34a1a2aa8da62b8691d8674e89a13d1a58e8b26cb253c2a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002961099803213$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2928959$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7485724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pathak, Irvin</creatorcontrib><creatorcontrib>Davis, Noelle L.</creatorcontrib><creatorcontrib>Hsiang, York N.</creatorcontrib><creatorcontrib>Quenville, Noel F.</creatorcontrib><creatorcontrib>Palcic, Branko</creatorcontrib><title>Detection of squamous neoplasia by fluorescence imaging comparing porfimer sodium fluorescence to tissue autofluorescence in the hamster cheek-pouch model</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Background: Early neoplastic changes in the oral cavity may be difficult to detect. Fluorescence imaging using porphyrin-derived drugs has been used to enhance detection of neoplasia. Autofluorescence has also been used for this purpose. This paper compares autofluorescence to porfimer sodium-induced fluorescence in the detection of neoplasia in the hamster cheek-pouch model.
Materials and methods: Neoplasia was induced in the hamster cheek pouch by the application of 9, 10-dimethyl-1,2-benzanthracene. Animals were imaged either with injection of drug (porfimer sodium) or without drug (autofluorescence). Imaging was carried out using a laser-induced fluorescence detection system. Biopies were performed on imaged sections and histologic grades were assigned.
Results: Porfimer sodium fluorescence provided 100% sensitivity and specificity in detection of neoplasia. The sensitivity and specificity with autofluorescence was 76% and 83%, respectively.
Conclusions: Autofluorescence provides an accurate means of detecting early neoplastic changes in the hamster cheek-pouch model; however, porfimer sodium imaging does improve detection rates.</description><subject>1,2-Benzanthracene</subject><subject>9,10-Dimethyl-1,2-benzanthracene - adverse effects</subject><subject>Animals</subject><subject>Antineoplastic Agents</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Carcinogens - adverse effects</subject><subject>Cheek pouch</subject><subject>Cricetinae</subject><subject>Disease Models, Animal</subject><subject>Double-Blind Method</subject><subject>Fluorescence</subject><subject>Fluorescent Dyes</subject><subject>Hematoporphyrin Derivative</subject><subject>Imaging</subject><subject>Laser induced fluorescence</subject><subject>Lasers</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesocricetus</subject><subject>Mouth Mucosa - drug effects</subject><subject>Mouth Mucosa - pathology</subject><subject>Mouth Neoplasms - chemically induced</subject><subject>Mouth Neoplasms - pathology</subject><subject>Neoplasms, Squamous Cell - chemically induced</subject><subject>Neoplasms, Squamous Cell - pathology</subject><subject>Oral cavity</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Porphyrins</subject><subject>Precancerous Conditions - chemically induced</subject><subject>Precancerous Conditions - pathology</subject><subject>ROC Curve</subject><subject>Sensitivity</subject><subject>Sensitivity and Specificity</subject><subject>Sodium</subject><subject>Squamous cell carcinoma</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUtv1DAUhS0EKkPhJ1SyBAtYBGwnTuwVqspTqsQCWFs3zk3HJYlTPyrNX-HX4umMRuqKlR_nu8fWOYRccPaeM95--MkYE5VuOXur9TvFasGr-gnZcNXpiitVPyWbE_KcvIjxthw5b-ozctY1Snai2ZC_nzChTc4v1I803mWYfY50Qb9OEB3QfkfHKfuA0eJikboZbtxyQ62fVwj73erD6GYMNPrB5fkxnjxNLsaMFHLyj50WmrZItzDHVKbtFvFPtfpst3T2A04vybMRpoivjus5-f3l86-rb9X1j6_fry6vK9vwLlVCtbqVDQqUysp-rBvgIADUAK3oi8gH1XYNKg28HjhIhaoXre2FrK0od-fk9cF3Df4uY0zm1uewlCeNUE3XSFbyLpQ8UDb4GAOOZg0li7AznJl9IeahELNP22htHgoxdZm7OLrnfsbhNHVsoOhvjjpEC9MYYLEunjChhdJSF-zjAcOSxL3DYKJ1-xgHF0p_ZvDuPx_5B__nqug</recordid><startdate>19951101</startdate><enddate>19951101</enddate><creator>Pathak, Irvin</creator><creator>Davis, Noelle L.</creator><creator>Hsiang, York N.</creator><creator>Quenville, Noel F.</creator><creator>Palcic, Branko</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>19951101</creationdate><title>Detection of squamous neoplasia by fluorescence imaging comparing porfimer sodium fluorescence to tissue autofluorescence in the hamster cheek-pouch model</title><author>Pathak, Irvin ; Davis, Noelle L. ; Hsiang, York N. ; Quenville, Noel F. ; Palcic, Branko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-2869654e2e58c5bf34a1a2aa8da62b8691d8674e89a13d1a58e8b26cb253c2a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>1,2-Benzanthracene</topic><topic>9,10-Dimethyl-1,2-benzanthracene - adverse effects</topic><topic>Animals</topic><topic>Antineoplastic Agents</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Carcinogens - adverse effects</topic><topic>Cheek pouch</topic><topic>Cricetinae</topic><topic>Disease Models, Animal</topic><topic>Double-Blind Method</topic><topic>Fluorescence</topic><topic>Fluorescent Dyes</topic><topic>Hematoporphyrin Derivative</topic><topic>Imaging</topic><topic>Laser induced fluorescence</topic><topic>Lasers</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesocricetus</topic><topic>Mouth Mucosa - drug effects</topic><topic>Mouth Mucosa - pathology</topic><topic>Mouth Neoplasms - chemically induced</topic><topic>Mouth Neoplasms - pathology</topic><topic>Neoplasms, Squamous Cell - chemically induced</topic><topic>Neoplasms, Squamous Cell - pathology</topic><topic>Oral cavity</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Porphyrins</topic><topic>Precancerous Conditions - chemically induced</topic><topic>Precancerous Conditions - pathology</topic><topic>ROC Curve</topic><topic>Sensitivity</topic><topic>Sensitivity and Specificity</topic><topic>Sodium</topic><topic>Squamous cell carcinoma</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pathak, Irvin</creatorcontrib><creatorcontrib>Davis, Noelle L.</creatorcontrib><creatorcontrib>Hsiang, York N.</creatorcontrib><creatorcontrib>Quenville, Noel F.</creatorcontrib><creatorcontrib>Palcic, Branko</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pathak, Irvin</au><au>Davis, Noelle L.</au><au>Hsiang, York N.</au><au>Quenville, Noel F.</au><au>Palcic, Branko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of squamous neoplasia by fluorescence imaging comparing porfimer sodium fluorescence to tissue autofluorescence in the hamster cheek-pouch model</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>1995-11-01</date><risdate>1995</risdate><volume>170</volume><issue>5</issue><spage>423</spage><epage>426</epage><pages>423-426</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>Background: Early neoplastic changes in the oral cavity may be difficult to detect. Fluorescence imaging using porphyrin-derived drugs has been used to enhance detection of neoplasia. Autofluorescence has also been used for this purpose. This paper compares autofluorescence to porfimer sodium-induced fluorescence in the detection of neoplasia in the hamster cheek-pouch model.
Materials and methods: Neoplasia was induced in the hamster cheek pouch by the application of 9, 10-dimethyl-1,2-benzanthracene. Animals were imaged either with injection of drug (porfimer sodium) or without drug (autofluorescence). Imaging was carried out using a laser-induced fluorescence detection system. Biopies were performed on imaged sections and histologic grades were assigned.
Results: Porfimer sodium fluorescence provided 100% sensitivity and specificity in detection of neoplasia. The sensitivity and specificity with autofluorescence was 76% and 83%, respectively.
Conclusions: Autofluorescence provides an accurate means of detecting early neoplastic changes in the hamster cheek-pouch model; however, porfimer sodium imaging does improve detection rates.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>7485724</pmid><doi>10.1016/S0002-9610(99)80321-3</doi><tpages>4</tpages></addata></record> |
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| ispartof | The American journal of surgery, 1995-11, Vol.170 (5), p.423-426 |
| issn | 0002-9610 1879-1883 |
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| subjects | 1,2-Benzanthracene 9,10-Dimethyl-1,2-benzanthracene - adverse effects Animals Antineoplastic Agents Biological and medical sciences Biopsy Carcinogens - adverse effects Cheek pouch Cricetinae Disease Models, Animal Double-Blind Method Fluorescence Fluorescent Dyes Hematoporphyrin Derivative Imaging Laser induced fluorescence Lasers Male Medical sciences Mesocricetus Mouth Mucosa - drug effects Mouth Mucosa - pathology Mouth Neoplasms - chemically induced Mouth Neoplasms - pathology Neoplasms, Squamous Cell - chemically induced Neoplasms, Squamous Cell - pathology Oral cavity Otorhinolaryngology. Stomatology Porphyrins Precancerous Conditions - chemically induced Precancerous Conditions - pathology ROC Curve Sensitivity Sensitivity and Specificity Sodium Squamous cell carcinoma Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Detection of squamous neoplasia by fluorescence imaging comparing porfimer sodium fluorescence to tissue autofluorescence in the hamster cheek-pouch model |
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