Synthesis of [4-(3-aryl-1,2,4-oxadiazol-5-ylmethylthio)-2-methylphenoxy]acetic acids as new potential PPAR agonists

Synthesis of [4-(3-aryl-1,2,4-oxadiazol-5-ylmethylthio)-2-methylphenoxy]acetic acids as new potential PPAR agonists

A five-step synthetic route to [4-(3-aryl-1,2,4-oxadiazol-5-ylmethylthio)-2-methyl-phenoxy]acetic acids, new potential agonists of type δ/β peroxisome proliferator-activated receptors (PPARδ/β), starting from substituted benzonitriles was developed.

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Veröffentlicht in:Russian chemical bulletin 2023-07, Vol.72 (7), p.1648-1653
Hauptverfasser: Minin, D. V., Popkov, S. V., Pesochinskaya, K. V., Aleksanov, D. R.
Format: Artikel
Sprache:eng
Schlagworte:
Acetic acid
Aromatic compounds
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Full Articles
Inorganic Chemistry
Organic Chemistry
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Zusammenfassung:A five-step synthetic route to [4-(3-aryl-1,2,4-oxadiazol-5-ylmethylthio)-2-methyl-phenoxy]acetic acids, new potential agonists of type δ/β peroxisome proliferator-activated receptors (PPARδ/β), starting from substituted benzonitriles was developed.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-023-3944-5