α-Amylase inhibitor based on the copper(II) complex with 2-[(dimethylamino)methyl]arbutin ligand: synthesis, molecular docking, and in vitro assay of the inhibition type

The aminomethylation of arbutin followed by complexation with copper diacetate resulted in the synthesis of 1,3-oxazine derivatives of arbutin, as well as the chelate O,N-complex: 1-(β- D -glucopyranosyl-1-oxy)-3-(dimethylaminomethyl)-4-hydroxybenzene diacetate cuprate. In silico and in vitro assays of the synthesized compounds show that the 2-cupra-1,3-oxazine derivative of arbutin is an uncompetitive inhibitor of the α-amylase enzyme.