Decellularized Liver Nanofibers Enhance and Stabilize the Long‐Term Functions of Primary Human Hepatocytes In Vitro (Adv. Healthcare Mater. 19/2023)

Decellularized Liver Nanofibers Enhance and Stabilize the Long‐Term Functions of Primary Human Hepatocytes In Vitro (Adv. Healthcare Mater. 19/2023)

Electrospinning In article 2202302 by Matt J. Kipper, Salman R. Khetani, and co‐workers, novel methods are developed to electrospin decellularized porcine liver extracellular matrix (ECM) and collagen I into nanofibers without needing synthetic polymer blends toward mimicking the complex composition...

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Veröffentlicht in:Advanced healthcare materials 2023-07, Vol.12 (19), p.n/a
Hauptverfasser: Liu, Jennifer S., Madruga, Liszt Y. C., Yuan, Yang, Kipper, Matt J., Khetani, Salman R.
Format: Artikel
Sprache:eng
Schlagworte:
Collagen (type I)
Extracellular matrix
Fibroblasts
Hepatocytes
Liver
Nanofibers
Polymer blends
Substrates
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Zusammenfassung:Electrospinning In article 2202302 by Matt J. Kipper, Salman R. Khetani, and co‐workers, novel methods are developed to electrospin decellularized porcine liver extracellular matrix (ECM) and collagen I into nanofibers without needing synthetic polymer blends toward mimicking the complex composition and topography of native liver ECM. Primary human hepatocytes display higher and long‐term functions on the nanofibers in monoculture and coculture with fibroblasts as compared to culture on conventional (adsorbed ECM) substrates
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.202370106