Synthesis and Biological Activity of 4-Fluorophenylcyclohexyl(tetrahydropyranyl)methyl-Substituted Aryloxypropanolamines

The alkylation of (4-fluorophenyl)acetonitrile with dibrompentane and 2,2'-dichlorodiethyl ether gave the corresponding nitriles, which were reduced with lithium aluminium hydride to obtain [1-(4-fluorophenyl)cyclohexyl]- and [1-(4-fluorophenyl)tetrahydro-2 H -pyran-4-yl]methanamines. Treatment...

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Veröffentlicht in:	Russian journal of organic chemistry 2023-05, Vol.59 (5), p.756-763
Hauptverfasser:	Aghekyan, A. A., Mkryan, G. G., Melikyan, G. S., Panosyan, H. A., Tsatinyan, A. S., Grigoryan, A. S., Gasparyan, H. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitrile Alkylation Aluminum hydrides Aromatic compounds Biological activity Chemistry Chemistry and Materials Science Lithium aluminum hydrides Metal hydrides Nitriles Organic Chemistry Oxazolidine Substitutes Synthesis
Online-Zugang:	Volltext
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