Synthesis and Biological Activity of 4-Fluorophenylcyclohexyl(tetrahydropyranyl)methyl-Substituted Aryloxypropanolamines

The alkylation of (4-fluorophenyl)acetonitrile with dibrompentane and 2,2'-dichlorodiethyl ether gave the corresponding nitriles, which were reduced with lithium aluminium hydride to obtain [1-(4-fluorophenyl)cyclohexyl]- and [1-(4-fluorophenyl)tetrahydro-2 H -pyran-4-yl]methanamines. Treatment...

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Veröffentlicht in:Russian journal of organic chemistry 2023-05, Vol.59 (5), p.756-763
Hauptverfasser: Aghekyan, A. A., Mkryan, G. G., Melikyan, G. S., Panosyan, H. A., Tsatinyan, A. S., Grigoryan, A. S., Gasparyan, H. V.
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Sprache:eng
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Zusammenfassung:The alkylation of (4-fluorophenyl)acetonitrile with dibrompentane and 2,2'-dichlorodiethyl ether gave the corresponding nitriles, which were reduced with lithium aluminium hydride to obtain [1-(4-fluorophenyl)cyclohexyl]- and [1-(4-fluorophenyl)tetrahydro-2 H -pyran-4-yl]methanamines. Treatment of the latter products with aryloxymethyloxiranes substituted in the aromatic ring resulted in the synthesis of. Some of the synthesized aryloxypropanolamines were transformed into the corresponding oxazolidines under the action of formalin.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428023050020