Kinetic disposition of albendazole in goats subclinically infected with gastrointestinal nematodes vis-à-vis naive animals following oral and intraruminal administration

The influence of subclinical nematodosis on the kinetic disposition of albendazole was evaluated in goats following oral and intraruminal administration. The disposition curves of its metabolites indicated increased uptake of the drug in parasitized goats following intraruminal compared to oral dosi...

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Veröffentlicht in:	Journal of helminthology 2008-03, Vol.82 (1), p.17-23
Hauptverfasser:	Dubey, A.K., Sanyal, P.K., Koley, K.M., Chaudhary, P.L., Mukherjee, K., Mandal, S.C., Pal, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Albendazole Albendazole - analogs & derivatives Albendazole - blood Albendazole - pharmacokinetics Animal shelters Animals Animals, Domestic Antibiotics. Antiinfectious agents. Antiparasitic agents Antinematodal Agents - pharmacokinetics Antiparasitic agents Biological and medical sciences Biological Availability Chromatography Drug dosages Drugs Feces - parasitology Female Goat Diseases - drug therapy Goat Diseases - parasitology Goats Half-Life Medical sciences Metabolites Nematoda - isolation & purification Nematode Infections - drug therapy Nematode Infections - veterinary Nematodes Oral administration Parasite Egg Count Parasites Pharmacokinetics Pharmacology. Drug treatments Plasma Rumen Uptake Worms
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Zusammenfassung:	The influence of subclinical nematodosis on the kinetic disposition of albendazole was evaluated in goats following oral and intraruminal administration. The disposition curves of its metabolites indicated increased uptake of the drug in parasitized goats following intraruminal compared to oral dosing (P
ISSN:	0022-149X 1475-2697
DOI:	10.1017/S0022149X07870817