Comment: A Quarter Century of Methodological Research in Response-Adaptive Randomization

Ivanova and Rosenberger discuss methodological research in response-adaptive randomization, highlighting examples under which response-adaptive randomization should be considered for use in practice. Response-adaptive randomization has been a challenging area in which to conduct research, not because of any difficulties in publishing methodology, but rather the biases that have been present since the 1980s and are still flourishing today. Some of these have been pointed out and debunked by Robertson et al.