The Role of Using Micronized Purified Flavonoid Fraction After Rubber Band Ligation in Hemorrhoidal Disease: A Retrospective Analysis

Aim: To investigate the effect of the addition of micronized purified flavonoid fraction (MPFF) on occurrence and severity of symptoms in patients who underwent rubber band ligation (RBL) for hemorrhoidal disease (HD). Method: Patients who underwent RBL for HD in a single clinic in 2020 were retrospectively assessed. Patients aged ≥ eighteen years treated by a single surgeon for stage II and III internal HD with RBL and MPFF or RBL alone were included. The patients were divided into those who received combined therapy (RBL+MPFF) and those who only had RBL. The presence of bleeding, pain, and/or itching and occurrence of prolapse were recorded at the time of admission and on visit 1 (seventh post-operative day) and visit 2 (28th post-operative day). Complications arising from RBL were also recorded. All patients were asked to evaluate general anal area comfort with a visual analog scale at admission and each visit. Results: The rate of bleeding on the first visit was significantly lower in the RBL+MPFF group compared to RBL alone (p