Isolation and Characterization of a Flavonoid and Analgesic activity of leaves of Bauhinia acuminata Linn
The present study investigated centrally and peripherally mediated analgesic activity of methanol extract of leaves of Bauhinia acuminata and isolation of active compounds by column chromatography with gradient elution using combination of different solvents. FTIR, 1H and 13C NMR spectral data of th...
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| Veröffentlicht in: | Research journal of pharmacy and technology 2023-05, Vol.16 (5), p.2177-2181 |
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| container_title | Research journal of pharmacy and technology |
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| creator | Chakraborty, Sudipta Nath Bala, Nripendra Das, Sudipta |
| description | The present study investigated centrally and peripherally mediated analgesic activity of methanol extract of leaves of Bauhinia acuminata and isolation of active compounds by column chromatography with gradient elution using combination of different solvents. FTIR, 1H and 13C NMR spectral data of the isolated compound established it to be a flavonol, quercetin. The analgesic activity of the extract was found to be dose dependent and effective in all the models tested being Acetic acid induced visceral pain model as the best (p |
| doi_str_mv | 10.52711/0974-360X.2023.00357 |
| format | Article |
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FTIR, 1H and 13C NMR spectral data of the isolated compound established it to be a flavonol, quercetin. The analgesic activity of the extract was found to be dose dependent and effective in all the models tested being Acetic acid induced visceral pain model as the best (p<0.01 in all the doses tested). In hot plate method the test extract showed significant analgesia (p<0.01) compared to the control only for 200 and 400mg/kg BWfor all the reaction times tested, but the 100mg mg/kg BW was able to show the same only after 45 min. Formalin induced tonic pain model also exhibited similar results that indicated better analgesia was achieved at late phase (10-30 min). The analgesic activity of this extract may be correlated with that of the available phytochemical data obtained for this plant which indicates the presence of flavonoids and alkaloids as the chief constituents in leaves. In all the test models the results were promising and near to that of the standards used indicating it’s competence in the pain and related therapies which may be validated by further clinical studies.</description><identifier>ISSN: 0974-3618</identifier><identifier>EISSN: 0974-360X</identifier><identifier>EISSN: 0974-306X</identifier><identifier>DOI: 10.52711/0974-360X.2023.00357</identifier><language>eng</language><publisher>Raipur: A&V Publications</publisher><subject>Acids ; Analgesics ; Chromatography ; Flavonoids ; Ions ; Pain ; Phytochemicals ; Solvents</subject><ispartof>Research journal of pharmacy and technology, 2023-05, Vol.16 (5), p.2177-2181</ispartof><rights>Copyright A&V Publications May 2023</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c144t-4475ca42e4700897487f257e1fcdfc9098b8699372d538b9cf35d3357a13a0563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids></links><search><creatorcontrib>Chakraborty, Sudipta</creatorcontrib><creatorcontrib>Nath Bala, Nripendra</creatorcontrib><creatorcontrib>Das, Sudipta</creatorcontrib><title>Isolation and Characterization of a Flavonoid and Analgesic activity of leaves of Bauhinia acuminata Linn</title><title>Research journal of pharmacy and technology</title><description>The present study investigated centrally and peripherally mediated analgesic activity of methanol extract of leaves of Bauhinia acuminata and isolation of active compounds by column chromatography with gradient elution using combination of different solvents. FTIR, 1H and 13C NMR spectral data of the isolated compound established it to be a flavonol, quercetin. The analgesic activity of the extract was found to be dose dependent and effective in all the models tested being Acetic acid induced visceral pain model as the best (p<0.01 in all the doses tested). In hot plate method the test extract showed significant analgesia (p<0.01) compared to the control only for 200 and 400mg/kg BWfor all the reaction times tested, but the 100mg mg/kg BW was able to show the same only after 45 min. Formalin induced tonic pain model also exhibited similar results that indicated better analgesia was achieved at late phase (10-30 min). The analgesic activity of this extract may be correlated with that of the available phytochemical data obtained for this plant which indicates the presence of flavonoids and alkaloids as the chief constituents in leaves. In all the test models the results were promising and near to that of the standards used indicating it’s competence in the pain and related therapies which may be validated by further clinical studies.</description><subject>Acids</subject><subject>Analgesics</subject><subject>Chromatography</subject><subject>Flavonoids</subject><subject>Ions</subject><subject>Pain</subject><subject>Phytochemicals</subject><subject>Solvents</subject><issn>0974-3618</issn><issn>0974-360X</issn><issn>0974-306X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNo9kE9LAzEQxYMoWGo_grDgeWv-brLHWqwWCl4UvIVpNmtTtklNtoX66c224lzmMfMY3vwQuid4Kqgk5BHXkpeswp9TiimbYsyEvEKj__H1vybqFk1S2uJclRKUqxFyyxQ66F3wBfimmG8ggultdD-XYWgLKBYdHIMPrjl7Zh66L5ucKbLTHV1_GlydhaNNg3qCw8Z5B3l92DkPPRQr5_0dummhS3by18foY_H8Pn8tV28vy_lsVRrCeV9yLoUBTi2XGKscXMmWCmlJa5rW1LhWa1XVNZO0EUyta9My0bD8MxAGWFRsjB4ud_cxfB9s6vU2HGLOnDRVLD_N6sxojMTFZWJIKdpW76PbQTxpgvUZrB6o6YGgHsDqM1j2C7a1ars</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Chakraborty, Sudipta</creator><creator>Nath Bala, Nripendra</creator><creator>Das, Sudipta</creator><general>A&V Publications</general><scope>AAYXX</scope><scope>CITATION</scope><scope>04Q</scope><scope>04S</scope><scope>04W</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20230501</creationdate><title>Isolation and Characterization of a Flavonoid and Analgesic activity of leaves of Bauhinia acuminata Linn</title><author>Chakraborty, Sudipta ; Nath Bala, Nripendra ; Das, Sudipta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c144t-4475ca42e4700897487f257e1fcdfc9098b8699372d538b9cf35d3357a13a0563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acids</topic><topic>Analgesics</topic><topic>Chromatography</topic><topic>Flavonoids</topic><topic>Ions</topic><topic>Pain</topic><topic>Phytochemicals</topic><topic>Solvents</topic><toplevel>online_resources</toplevel><creatorcontrib>Chakraborty, Sudipta</creatorcontrib><creatorcontrib>Nath Bala, Nripendra</creatorcontrib><creatorcontrib>Das, Sudipta</creatorcontrib><collection>CrossRef</collection><collection>India Database</collection><collection>India Database: Business</collection><collection>India Database: Science & Technology</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Research journal of pharmacy and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chakraborty, Sudipta</au><au>Nath Bala, Nripendra</au><au>Das, Sudipta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolation and Characterization of a Flavonoid and Analgesic activity of leaves of Bauhinia acuminata Linn</atitle><jtitle>Research journal of pharmacy and technology</jtitle><date>2023-05-01</date><risdate>2023</risdate><volume>16</volume><issue>5</issue><spage>2177</spage><epage>2181</epage><pages>2177-2181</pages><issn>0974-3618</issn><eissn>0974-360X</eissn><eissn>0974-306X</eissn><abstract>The present study investigated centrally and peripherally mediated analgesic activity of methanol extract of leaves of Bauhinia acuminata and isolation of active compounds by column chromatography with gradient elution using combination of different solvents. FTIR, 1H and 13C NMR spectral data of the isolated compound established it to be a flavonol, quercetin. The analgesic activity of the extract was found to be dose dependent and effective in all the models tested being Acetic acid induced visceral pain model as the best (p<0.01 in all the doses tested). In hot plate method the test extract showed significant analgesia (p<0.01) compared to the control only for 200 and 400mg/kg BWfor all the reaction times tested, but the 100mg mg/kg BW was able to show the same only after 45 min. Formalin induced tonic pain model also exhibited similar results that indicated better analgesia was achieved at late phase (10-30 min). The analgesic activity of this extract may be correlated with that of the available phytochemical data obtained for this plant which indicates the presence of flavonoids and alkaloids as the chief constituents in leaves. In all the test models the results were promising and near to that of the standards used indicating it’s competence in the pain and related therapies which may be validated by further clinical studies.</abstract><cop>Raipur</cop><pub>A&V Publications</pub><doi>10.52711/0974-360X.2023.00357</doi><tpages>5</tpages></addata></record> |
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| subjects | Acids Analgesics Chromatography Flavonoids Ions Pain Phytochemicals Solvents |
| title | Isolation and Characterization of a Flavonoid and Analgesic activity of leaves of Bauhinia acuminata Linn |
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