Synthesis, Antimicrobial Evaluation, and In Silico Molecular Docking Studies of Chalcone-Based 1,2,3-Triazoles
A series of chalcone-based 1,2,3-triazole compounds was synthesized Condensation of aldehydes and ketones results in the formation of chalcones. Terminal alkyne of chalcones and different aryl azides cyclization produced chalcone-based 1,2,3-triazoles through 1,3-dipolar cycloaddition (click reactio...
Gespeichert in:
Veröffentlicht in: | Russian journal of general chemistry 2023-05, Vol.93 (5), p.1162-1170 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | A series of chalcone-based 1,2,3-triazole compounds was synthesized Condensation of aldehydes and ketones results in the formation of chalcones. Terminal alkyne of chalcones and different aryl azides cyclization produced chalcone-based 1,2,3-triazoles through 1,3-dipolar cycloaddition (click reaction). The compounds were screened to evaluate their in vitro antimicrobial activities against
Bacillus cereus, Escherichia coli
bacteria and
Aspergillus niger
fungal strains. The analogues of 2-methyl, 4-chloro, 3-trifluormethyl, ester and 3,5-dichloro substitutions showed excellent zone of inhibition compared to ampicillin and bavistin drugs. Molecular docking studies showed good binding interactions with selected proteins glucosamine-6-phosphate and 3-phytase A of
E. coli
and
A. niger
, respectively. |
---|---|
ISSN: | 1070-3632 1608-3350 |
DOI: | 10.1134/S1070363223050171 |