Synthesis of Arylamines via a Tandem Petasis Borono‐Mannich/ Nucleophilic Substitution Reaction

An efficient and practical one‐pot reaction for the synthesis of diarylmethyl anilines from easy available materials of salicylaldehydes, arylboronic acids and aromatic amines has been successfully developed. All the reactions proceed smoothly under transition‐metal‐free conditions via a p‐TSA promoted tandem Petasis borono‐Mannich/ nucleophilic substitution reaction, providing highly functionalized amines with wide functional groups in good to excellent yields. A reasonable explanation for this transformation was suggested. An efficient and practical method for the preparation of diarylmethyl anilines via a one‐pot three‐component reaction from easy available salicylaldehydes, arylboronic acids and aromatic amines has been developed.