Pd‐Catalysed Diastereoselective Synthesis of aza‐Spirocyclic P‐Stereogenic Phosphine Oxides

Phosphine oxides and spirocyclic compounds are privileged molecules widely employed in a variety of catalytic transformations either as chiral ligands for metals or bifunctional organocatalysts. Herein, we developed a Pd‐catalysed cross‐coupling reaction to synthesize spirocyclic amino‐phosphine oxides with a P‐stereogenic centre which could serve as potential P*(O), N‐ligands or organocatalysis. We designed a Pd‐catalyzed cross‐coupling reaction to synthesize diastereoselective spirocyclic amino‐phosphine oxides with a P‐stereogenic center. These potential P*(O), N‐ligands contain both electronic donor and H donor/acceptor properties, which may be used to promote asymmetric catalytic reactions with high selectivity and efficiency.