Effects on thrombocytic hemostasis of a new derivate indolinone

Effects on thrombocytic hemostasis of a new derivate indolinone

Objective. Specific activity of an antiplatelet drug of indolinone series (codenamed DI) was studied in vitro in a model of ADP-induced platelet aggregation in vitro and in vivo in a model of streptozotocininduced diabetes mellitus in rats. Material and Methods. Acetylsalicylic acid and dipyridamole...

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Veröffentlicht in:Bangladesh journal of medical science (Ibn Sina Trust) 2019, Vol.18 (3), p.574-576
Hauptverfasser: Bykov, VV, Serebrov, V Yu, Udut, VV, Udut, EV, Fisenko, VP
Format: Artikel
Sprache:eng
Schlagworte:
Aspirin
Diabetes
Drug dosages
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Zusammenfassung:Objective. Specific activity of an antiplatelet drug of indolinone series (codenamed DI) was studied in vitro in a model of ADP-induced platelet aggregation in vitro and in vivo in a model of streptozotocininduced diabetes mellitus in rats. Material and Methods. Acetylsalicylic acid and dipyridamole were used as reference drugs. In vitro tests have demonstrated that DI exhibits antiplatelet activity in a wide range of concentrations (0,75×10-6 – 1.5×10-5 М, р
ISSN:2223-4721
2076-0299
DOI:10.3329/bjms.v18i3.41628