Pyridazine Synthesis from 1,2,4,5-Tetrazines and Alkynes in 1,1,1,3,3,3-Hexafluoro-2-propanol through the Inverse Electron Demand Diels–Alder Reaction

Pyridazine Synthesis from 1,2,4,5-Tetrazines and Alkynes in 1,1,1,3,3,3-Hexafluoro-2-propanol through the Inverse Electron Demand Diels–Alder Reaction

A facile method to synthesize pyridazines from 1,2,4,5-tetrazines and alkynes is disclosed. The reaction was significantly facilitated by 1,1,1,3,3,3-hexafluoro-2-propanol. The wide scope and the predictable regioselectivity by theoretical calculations will serve to synthesize a wide range of multis...

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Veröffentlicht in:Bulletin of the Chemical Society of Japan 2022-12, Vol.95 (12), p.1741-1746
Hauptverfasser: Yamamoto, Chika, Suzuki, Minori, Yoshida, Suguru
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes
Diels-Alder reactions
Mathematical analysis
Pyridazines
Regioselectivity
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Zusammenfassung:A facile method to synthesize pyridazines from 1,2,4,5-tetrazines and alkynes is disclosed. The reaction was significantly facilitated by 1,1,1,3,3,3-hexafluoro-2-propanol. The wide scope and the predictable regioselectivity by theoretical calculations will serve to synthesize a wide range of multisubstituted pyridazines.
ISSN:0009-2673
1348-0634
DOI:10.1246/bcsj.20220267