Aerobic oxidation of 2‐tert‐butyl phenol within gas–liquid segmented flow: Mass transfer characteristics and scale‐up

Quantifying the mass transfer of gas–liquid segmented flow in practical reactions is of significant for the scale‐up design. However, there is a lack of theoretical guidance to predict operational conditions to meet required the mass transfer in a selective dimension‐enlarged microreactor. Herein, t...

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Veröffentlicht in:AIChE journal 2023-07, Vol.69 (7), p.n/a
Hauptverfasser: Liu, Ping, Zhang, Jiawei, Liu, Kefeng, Hu, Xuesheng, Gao, Fei, Du, Le, Zhu, Jiqin
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Sprache:eng
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Zusammenfassung:Quantifying the mass transfer of gas–liquid segmented flow in practical reactions is of significant for the scale‐up design. However, there is a lack of theoretical guidance to predict operational conditions to meet required the mass transfer in a selective dimension‐enlarged microreactor. Herein, the oxidation of 2‐tert‐butyl phenol (2‐TBP) was performed in a selective dimension‐enlarged capillary microreactor of 4.35 mm i.d. and optimal operation conditions were obtained. A high 2‐tert‐butyl‐1,4‐benzoquinone (2‐TBQ) yield of 73% was achieved within 6 min. Moreover, a quantitative method to assess the mass transfer of gas–liquid segmented flow in practical reaction was developed by introducing a circulation frequency, fcir, which could provide theoretical guidance to predict operating conditions for the scale‐up production. The 2‐TBQ productivity is significantly increased from 0.0061 to 0.5068 kg/h, that is, an increase of 83 times, by selective dimension enlarging from 2 mm to 4.35 mm with predicted operating conditions.
ISSN:0001-1541
1547-5905
DOI:10.1002/aic.18057