IDDF2023-ABS-0278 Associations between dietary fat and non-alcoholic fatty liver disease (NAFLD) among us adults

BackgroundAn increasing amount of research suggests that moderate dietary fat intake would have positive effects on health. Nevertheless, studies on the relationship between dietary fat intake and NAFLD are limited, and a lack of consensus exists regarding the implementation of dietary recommendations. Saturated fatty acids (SFA) intake was reported to increase intrahepatic triglyceride content, leading to an increased risk of NAFLD, whereas moderate intake of unsaturated fatty acids has been shown to have a protective effect. Thus, the objective of this study is to investigate the relationship between dietary fat intake and NAFLD in the United States general population and determine an appropriate range of intake for future reference.MethodsThis study conducted an analysis using data from the 2017-2018 cycle of the NHANES, and a total of 3214 subjects were included (IDDF2023-ABS-0278 Figure 1. Flowchart of the study). NAFLD was defined as Controlled Attenuation Parameter (CAP) values ≥ 263 dB/m, which were assessed through vibration-controlled transient elastography. Dietary intake was obtained through a validated 2-day dietary recall.ResultsOf the 3214 subjects in the study cohort, NAFLD was present in 1642 (51.1%), who were more likely to be older, male, have a higher body mass index (BMI) and energy intake, but lower polyunsaturated fatty acid (PUFA) intake. Subjects in the highest quartile of PUFA intake (>21.0 g/day) had decreased risk of NAFLD compared to the lowest quartile (