An Investigation of Inverted Core@Shell Nanostructure for Efficacious Magnetic Hyperthermia Applications

Magnetic hyperthermia, a notable technique for tumor ministration, has opened up a novel account for biomedical research. Magnetic nanoparticles (MNPs) which are sensitive to heat liberation on exposition to the small magnetic fields are an essential obligation for this application. Exchange interactivity through a bimagnetic core@shell (CS) nanostructure is one novel approach to potentially meet the desirable atmosphere for productive hyperthermia treatment. This work reports on the microstructural and magnetic property of an unusual CS arrangement with antiferromagnetic NiO (N) as the core material mounted over by a ferrimagnetic shell Fe3O4 (F) desiring to constructively tune the heating efficiency of the Fe3O4 MNPs. The magnetic investigation displays an enormous exchange interaction at the CS interface resulting in huge relocation of the hysteresis loop authenticating the exchange bias effect (EBE). The specific absorption rate (SAR) or the heat dissipation of the MNPs for bare Fe3O4 and CS NiO@Fe3O4 (N@F) are compared. The outcome genuinely results in a huge contrast, where the SAR for CS N@F is greatly intensified by over 44% compared to the bare F sample. These findings, therefore, lay out a distinctive way to ameliorate the theranostic approach by making use of the MNPs. In hyperthermia, magnetic nanoparticles are waged to defeat the cancer cells through heat dissipation via the alternating magnetic field. An inverted core@shell NiO@Fe3O4 is devised to tune the magnetic anisotropy energy and it authenticates a surge in the heating efficiency by over 44% in contrast to the single‐material Fe3O4.