A New Macrolide from Penicillium sp. SO02

A New Macrolide from Penicillium sp. SO02

One new macrolide sumatraenseride ( 1 ), along with four known macrolides ( 2 – 5 ) and one polyketide ( 6 ), was isolated from a strain of the fungus, Penicillium sp . SO02. The structure of 1 was elucidated by IR, UV, HR-ESI-MS, NMR spectra, and CD data. The cytotoxic activities of compound 1 agai...

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Veröffentlicht in:Chemistry of natural compounds 2023-03, Vol.59 (2), p.327-330
Hauptverfasser: Sang, Yining, Wang, Jia, Tang, Siqi, Zhang, Peng
Format: Artikel
Sprache:eng
Schlagworte:
Antifungal agents
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Fungi
Metabolites
NMR
Nuclear magnetic resonance
Organic Chemistry
Plant Sciences
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Zusammenfassung:One new macrolide sumatraenseride ( 1 ), along with four known macrolides ( 2 – 5 ) and one polyketide ( 6 ), was isolated from a strain of the fungus, Penicillium sp . SO02. The structure of 1 was elucidated by IR, UV, HR-ESI-MS, NMR spectra, and CD data. The cytotoxic activities of compound 1 against three human tumor cell lines were also tested, with IC 50 values of 6.32 μM (HepG2), 18.38 μM (A875), and 90.23 μM (H460).
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-023-03986-w