Two New Phenolic Compounds with Aldose Reductase Inhibitory Activities from Polygonatum cyrtonema Leaves

Two New Phenolic Compounds with Aldose Reductase Inhibitory Activities from Polygonatum cyrtonema Leaves

Two new diastereoisomeric phenolic compounds ( 1 , 2 ) have been isolated from the methanol extract of Polygonatum cyrtonema Hua leaves. Their structures were elucidated as (1S,2R) and (1S,2S)-1-(4-hydroxy-3-methoxyphenyl)-1-ethoxypropan-2-ols by spectroscopic data ( 1 H NMR, 13 C NMR, HSQC, HMBC, H...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemistry of natural compounds 2023-03, Vol.59 (2), p.272-274
Hauptverfasser: Zhao, Zi-Yang, Zhang, Yu-Qian, Chen, Jia, Huang, Jin-Hua, Zhao, Chun-Chao, Shao, Jian-Hua
Format: Artikel
Sprache:eng
Schlagworte:
aldehyde reductase
Aldose reductase
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
methanol
Monosaccharides
NMR
Nuclear magnetic resonance
Organic Chemistry
Phenols
Plant Sciences
Polygonatum cyrtonema
Reductases
spectral analysis
Sugars
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Two new diastereoisomeric phenolic compounds ( 1 , 2 ) have been isolated from the methanol extract of Polygonatum cyrtonema Hua leaves. Their structures were elucidated as (1S,2R) and (1S,2S)-1-(4-hydroxy-3-methoxyphenyl)-1-ethoxypropan-2-ols by spectroscopic data ( 1 H NMR, 13 C NMR, HSQC, HMBC, HR-ESI-MS, and ORD). In addition, compounds 1 and 2 displayed potential aldose reductase inhibitory activities with IC 50 values of 29.05 and 22.38 μM, respectively.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-023-03974-0