Construction of PAMAM-based Nanocomplex Conjugated with Pt(IV)-complex and Lauric Acid Exerting Both Anti-tumor and Antibacterial Effects

Oxaliplatin is the common chemotherapy drug for the treatment of colorectal cancer (CRC), however, the harmful Fusobacterium nucleatum ( Fn ) that existed in the CRC tumor tissues leads to extreme drug resistance to oxaliplatin, which reduces the anticancer efficiency. Here we fabricated a new dendrimer-based nanocomplex with anti-tumor and antibacterial dual-functions through conjugating Pt(IV)-complex and lauric acid (LA) to the dendritic carrier PAMAM (G=3). The synthesized PAMAM-Pt-LA nanoparticle was further coated with hyaluronic acid (HA) on its surface through electrostatically interaction in order to enhance biocompatibility and tumor targeting. The biocompatibility, anti-tumor activity and antibacterial activity of PAMAM-Pt-LA@HA nanocomplex were evaluated in vitro. The results showed that the PAMAM-Pt-LA@HA nanocomplex ehxibited a good biocompatibility, high anti-colorectal cancer activity and high anti- Fn activity. This dual-functional nanocomplex provides a new method to develop anticancer nanomedicines that will be more therapeutically efficacious and less toxic than oxaliplatin for the treatment of CRC.