Synthesis of Diethyl 6-Amino-1,4-diaryl-2-oxo-1,2,3,4-tetrahydropyridin-3,5-dicarboxylates Based on the Reaction of Arylmethylidenecyanoacetic Esters with N-Arylamidoesters of Malonic Acid

Synthesis of Diethyl 6-Amino-1,4-diaryl-2-oxo-1,2,3,4-tetrahydropyridin-3,5-dicarboxylates Based on the Reaction of Arylmethylidenecyanoacetic Esters with N-Arylamidoesters of Malonic Acid

The reaction of arylmethylidenecyanoacetic esters with N -arylamides of malonic acid led to the formation of previously unknown diethyl 6-amino-1,4-diaryl-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarboxylates in 15–83% yields. Antibacterial activity of some obtained compounds was studied.

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Veröffentlicht in:Russian journal of general chemistry 2023-04, Vol.93 (4), p.787-794
Hauptverfasser: Avagyan, K. A., Sargsyan, M. S., Badasyan, A. E., Sargsyan, A. A., Manukyan, A. G., Panosyan, G. A., Ayvazyan, A. G., Khachatryan, A. Kh
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Esters
Pyridine
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Zusammenfassung:The reaction of arylmethylidenecyanoacetic esters with N -arylamides of malonic acid led to the formation of previously unknown diethyl 6-amino-1,4-diaryl-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarboxylates in 15–83% yields. Antibacterial activity of some obtained compounds was studied.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363223040035