Biomineralized CO gas-releasing nanoprodrug for endoplasmic reticulum stress mediated cancer therapy

The anti-tumor effect of therapeutic carbon monoxide (CO) has been considered concerning the electron transport chain on the inner mitochondrial membrane. Herein, a tumor microenvironment and photo-responsive CO nanoplatform Ca-Flav nanoparticles (NPs) were constructed through biomineralizing acrylo...

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Veröffentlicht in:Nano research 2023-05, Vol.16 (5), p.7373-7382
Hauptverfasser: Gu, Rui, Yang, Wanlan, Han, Lifei, Liu, Chao, Xu, Yatao, Liu, Yunlong, Si, Weili, Wang, Wenjun, Dong, Xiaochen
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Sprache:eng
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Zusammenfassung:The anti-tumor effect of therapeutic carbon monoxide (CO) has been considered concerning the electron transport chain on the inner mitochondrial membrane. Herein, a tumor microenvironment and photo-responsive CO nanoplatform Ca-Flav nanoparticles (NPs) were constructed through biomineralizing acryloyl-modified flavonol, which could release CO both in normoxia and hypoxia conditions upon irradiation at tumor lesion. The in vitro experiments demonstrated that the endoplasmic reticulum stress-related signal pathways could be activated through oxidative stress caused by CO mediated mitochondrial biogenesis and calcium ion turbulence induced by Ca 3 (PO 4 ) 2 acidolysis, resulting in mitochondrial dysfunction and cell apoptosis. In addition, the Ca-Flav NPs exhibited excellent biocompatibility and tumor inhibition effect in vivo. This work provides new insight into the potential characteristics of CO, paving a new way to engineer more efficient treatment based on CO.
ISSN:1998-0124
1998-0000
DOI:10.1007/s12274-023-5458-8