Evaluation of Anti-Thrombotic Activity of Astragalus Membranaceus Var. Mongholicus) Root Extract: In Vitro

Thrombotic diseases, especially heart diseases and cerebrovascular thrombosis, are primary causes of death and their incidence has been increasing annually. Traditional Indian medicine and the use of plant drugs against various diseases are receiving considerable attention nowadays. Astragalus membranaceus var. is very much used as a therapeutic agent in traditional and folklore medicine. Thus, this present research work was conducted to appraise the antithrombotic activity of aqueous root extract of A. membranaceus (AMRE) using in vitro experiments such as: Clotting Time Assay, Thrombolytic Activity, Determination of in-vitro Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT), Calcium chloride induced clotting time assay by ELISA, and Anti-coagulant activity by plasma re-calcification method. The results were analysed by one-way Analysis of Variance (ANOVA). The results showed more significant anti-thrombotic activity by preventing the formation of blood clots and thromboembolic disorders.