Epigallocatechin-3-Gallate Inhibits Proliferation And Expression of TGF-β1 in Human Pterygium Fibroblast

ntroduction: Pterygium is a degenerative illness defined by the formation of fibrovascular tissue on the ocular surface. The recurrence of this condition, which is accompanied by inflammation and increasing fibrovascular growth, is regarded as its key therapeutic challenge. Epigallocatechin gallate (EGCG) has demonstrated anti-inflammatory, antioxidative, and antiangiogenic benefits in many models of ocular illness. Our study aimed to determine the efficacy of EGCGon pterygium fibroblast proliferation and expression of TGF-β1. Methods: Pterygium fibroblast from tissue explants during pterygium surgery was cultured and treated withEGCG 25,50, and 100 µM. Proliferation was assessed using the CCK-8 assay. The expression of TGFβ1 was determined with immunofluorescence staining and the intensity measurement was done using ImageJ software. Results: EGCG significantly inhibited pterygium fibroblast proliferation and expression of TGF-β1 (p