Green synthesis of CeVO4 nanoparticles using Azadirechta indica leaves extract and their promising applications as an antioxidant and anticancer agent

This investigation reports an eco-friendly fabrication of cerium vanadate nanoparticles (CeVO 4 NPs) for the first time by an utterly green approach using Azadirachta indica leaves extract as a natural fuel. Textural properties of the as-prepared CeVO 4 NPs, such as structural, topological, and optical, were explored through X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FTIR), UV-visible diffuse reflectance spectra (DRS), field-emission scanning electron microscope (FESEM), energy dispersive X-ray analysis (EDX), high-resolution transmission electron microscopy (HRTEM), and zeta potential techniques. These results indicated that the as-synthesized NPs revealed a pseudo-spherical shape with a size of 43 nm. Moreover, as-prepared NPs were subjected to anticancer performance against HeLa cancer cell lines using MTT assays. In addition, the antioxidant efficacy of biosynthesized CeVO 4 NPs was scrutinized using DPPH and ABTS assays. Therefore, our study presents a facile, safe, cheap, rapid, and greener approach for producing CeVO 4 NPs and opening a new door for clinical applications. Graphical Abstract This investigation reports an eco-benevolent fabrication of cerium vanadate nanoparticles (CeVO 4 NPs) for the first time by an entirely green chemistry approach using Azadirachta indica leaves extract as a natural fuel. The physicochemical characteristics of the as-prepared CeVO 4 NPs, such as structural, topological, and optical, were explored through XRD, FTIR, UV-DRS, FESEM-EDX, HRTEM, and zeta potential techniques. Moreover, as-synthesized NPs were subjected to anticancer performance against HeLa cancer cell lines and antioxidant efficacy using DPPH and ABTS assays. Therefore, our study presents a facile, safe, affordable, swift and greener approach for producing CeVO 4 NPs and opening a new door for clinical applications. Highlights First-time synthesis of CeVO 4 nanoparticles using Azadirachta indica leaves extract through a green chemistry approach. Textural properties of CeVO 4 nanoparticles were revealed through XRD, FTIR, UVDRS, FESEM, EDX-mapping, HRTEM-SAED, and zeta potential techniques. The as-synthesized CeVO 4 nanoparticles evinced a pseudo-spherical shape with a size of 43 nm. Greenly produced CeVO 4 nanoparticles exhibited excellent anticancer (HeLa cell line) and antioxidant (DPPH & ABTS assays) potentials.