Eugenol Loaded Ag-Ti-Co Nanocomposite as a Promising Antimicrobial and Antioxidative Agent

The present study aims to synthesize and characterize eugenol-loaded nanocomposite (using Syzygium aromaticum ), followed by drug loading and analysis of drug release kinetics using standard procedure. UV–Vis spectroscopy showed absorption band at 258 nm, FTIR revealed the availability of eugenol, and SEM analysis and X-ray diffractometer examination revealed average particle diameter of 42.67 nm with orthorhombic structure. Energy dispersive X-ray (EDAX), Zeta, and size distribution pattern also confirmed the elemental composition, formation of stable nanocomposite, and uniformity of synthesized nanocomposite, respectively. MIC value obtained for Escherichia coli , Staphylococcus aureus , and Pseudomonas aeruginosa was 6.25 μg/ml, and for Proteus mirabilis , it is 3.25 μg/ml. MBC value for Escherichia coli and Proteus mirabilis was 12.5 μg/ml, and for Staphylococcus aureus and Pseudomonas aeruginosa , it was 25 μg/ml. Antioxidant studies revealed that Eu@NC showed significant DPPH free radical scavenging activity. This biosynthesized Eu@NC with enhanced antibacterial activity could be less toxic to environment and an eco-friendly approach. Graphical Abstract Preparation of powdered clove buds and extraction of phytochemicals, visible changes in the salt solution after addition of plant extract, eugenol loading through Sonicator, characterization and analysis of drug release kinetics, evaluation of antibacterial and antioxidant activity.