Regioselective synthesis of 2-aryl-5-(polyfluoroalkyl)pyridazin-3-ones based on 2-arylhydrazinylidene 1,3-dicarbonyl compounds

Regioselective synthesis of 2-aryl-5-(polyfluoroalkyl)pyridazin-3-ones based on 2-arylhydrazinylidene 1,3-dicarbonyl compounds

Polyfluoroalkyl-containing 2-arylhydrazinylidene 1,3-dicarbonyl compounds cyclize with ethyl (triphenylphosphoranylidene)acetate chemo- and regioselectively at the polyfluoroacyl—hydrazone moiety to form 6-carbonyl-functionalized 2-aryl-5-(polyfluoroalkyl)-pyridazin-3-ones. The regioselectivity of c...

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Veröffentlicht in:Russian chemical bulletin 2023-04, Vol.72 (4), p.972-978
Hauptverfasser: Elkina, N. A., Shchegolkov, E. V., Burgart, Ya. V., Perminova, A. N., Saloutin, V. I.
Format: Artikel
Sprache:eng
Schlagworte:
Aromatic compounds
Carbonyl compounds
Carbonyls
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Full Articles
Hydrazones
Inorganic Chemistry
Organic Chemistry
Regioselectivity
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Zusammenfassung:Polyfluoroalkyl-containing 2-arylhydrazinylidene 1,3-dicarbonyl compounds cyclize with ethyl (triphenylphosphoranylidene)acetate chemo- and regioselectively at the polyfluoroacyl—hydrazone moiety to form 6-carbonyl-functionalized 2-aryl-5-(polyfluoroalkyl)-pyridazin-3-ones. The regioselectivity of cyclizations was studied by GC/MS.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-023-3862-8