Topical nano hydrogel formulation of annona muricata extract enrich with zinc for improved therapy design and evaluation

Transdermal drug delivery system preparations are designed for application to the skin or to specific mucosal surfaces for local action or topically applied penetration of medication, as well as for emollient or protective action. In this study, we established and characterized polymer-based hydrogels in order to investigate their effectivity as topical drug delivery systems of Annona muricata extract enrich with zinc to confirm the possibility of inherent ulcus diabeticus properties in these hydrogels. We report here the use of four different Carbomer-940 based formulations concentrations 0.5%; 1.0%; 2.0%; and 3.0%. It was evaluated for physical parameters, pH, viscosity, and Spreadibility. Out of the four formulations the 2.0% was found to be better in all aspects. The characterize of nano-hydrogel base also was tested by using particle size analyzer. As a result, it can be used as a formulation for further application.