A Sc(OTf) 3 -catalyzed one-pot two-step approach for spiro-oxindole dihydropyridine derivatives initiated by N -olefination of MBH carbonates
A series of polyfunctionalized spiro-oxindole dihydropyridine frameworks have been synthesized via an efficient Sc 3+ -catalyzed one-pot stepwise reaction. This stepwise strategy involved the cleavage and formation of multiple C–X/C–C bonds, enabled by the N -olefination, Meinwald rearrangement and...
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Veröffentlicht in: | Organic Chemistry Frontiers 2023-05, Vol.10 (9), p.2294-2300 |
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Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | A series of polyfunctionalized spiro-oxindole dihydropyridine frameworks have been synthesized
via
an efficient Sc
3+
-catalyzed one-pot stepwise reaction. This stepwise strategy involved the cleavage and formation of multiple C–X/C–C bonds, enabled by the
N
-olefination, Meinwald rearrangement and inverse-electron-demand aza-Diels–Alder reaction. This transformation exhibited many advantages, including readily available starting materials, mild reaction conditions, and high chemoselectivities and yields. |
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ISSN: | 2052-4129 2052-4110 2052-4129 2052-4110 |
DOI: | 10.1039/D3QO00060E |