Studies on Degradation of Flucloxacillin Sodium in Binary and Ternary Systems through UV-Spectroscopy and pH Measurement

Flucloxacillin sodium (FluNa) is a narrow spectrum beta-lactam (β-lactum) antibiotic of penicillin class which is widely used in the treatment of bacterial infections. Degradation of flucloxacillin sodium (FluNa) in aqueous and different solvent systems was monitored by UV spectroscopy and pH measurement. The effects of carbohydrates (glucose, fructose), urea and thiourea on the stability of flucloxacillin sodium were examined. The degradation of degraded product of flucloxacillin sodium was also studied. Degradation pathway of flucloxacillin sodium in aqueous and different solvents suggests that the stability of FluNa in aqueous glucose and fructose is near to aqueous solution of FluNa and conversely for urea and thiourea system its changes abruptly. And the absorbance intensity at 339nm (for degradation product) decreases with increase of time i.e. degraded product amount in solution changes with time. These outcomes are very helpful for determining the real therapeutic doses of drugs.