Microwave Induced Solid Dispersion as a Novel Technique for Enhancing Solubility of Rifampicin

The aim of this work was to enhance the solubility of poorly soluble drugs like Rifampicin and further study the effect of enhanced solubility on the dissolution rate. Microwave induced solid dispersion is novel technique to enhance solubility of poorly soluble drugs. Rifampicin is Anti tuberculosis drug, used either in a combination with other drugs or without any combination. But as it belongs to BCS Class-II (low solubility & high permeability) it shows low bioavailability so the primary objective was to enhance solubility of Rifampicin. The attempt was made to enhance a solubility of poorly water soluble drug Rifampicin by using Microwave Induced Solid Dispersion. HPMC E5LV was used as dispersion media for the solid dispersion. This study was involved preformulation study of drug, characterization of solid dispersion and evaluation of formulation.Solid dispersions were prepared by Kneading Method, Solvent Evaporation Method and Microwave Induced Method. Further optimization was performed to select optimum ratio of drug to polymer. Optimized solid dispersions were selected for a capsule formulation. Evaluation of solid dispersion & capsules were performed. The microwave-induced solid dispersion method is a promising approach to enhancing the solubility and dissolution rate of Rifampicin having low solubility in water.