Magnetic Resonance Brain Imaging, Manganese, and Ammonia Changes in Chronic Liver Disease: Reversibility post-Liver Transplantation

Background: In patients with chronic liver disease, the presence of hepatocellular failure and/or portosystemic shunting lead to structural and functional brain changes. These changes are due to an increase in substances that are efficiently metabolized by the liver under normal circumstances. These abnormalities can be detected by MRI and magnetic resonance spectroscopy (MRS). Objective: This study aims to evaluate changes in MR brain imaging, manganese, and ammonia levels in patients with chronic liver disease. Additionally, to assess the reversibility of these changes post-living donor liver transplantation. Methods: The study included 10 adult male patients with CLD who underwent LDLT and 10 age and sex-matched healthy control subjects. All patients were subjected to clinical examination, routine labs, MR and MRS examinations of the brain. Follow-up MRI and MRS brain examination, as well as ammonia and manganese levels, were performed 6 to 9 months post-liver transplantation. Results: The CHILD score ranged from 7 to 13 with a mean of 10.4±1.8, whereas the MELD score ranged from 12 to 22 with a mean of 17.5±3.4. Ammonia levels pre-transplantation (mean 60±7.8) decreased significantly post-transplantation (mean 45.8±7.0) (P