Development spectrophotometric determination of trifluoperazine hydrochloride in dosage forms by used oxidative coupling reaction
The determination of triflouperazine hydrochloride in pure and dose forms has been developed using a simple spectrophotometric approach. The method employs an oxidative coupling reaction with sulfanilic acid in the presence of N-bromosuccinimide to produce a red-violet colored product with a maximum...
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| creator | Hussein, Ali M. Othman, Nebbel S. |
| description | The determination of triflouperazine hydrochloride in pure and dose forms has been developed using a simple spectrophotometric approach. The method employs an oxidative coupling reaction with sulfanilic acid in the presence of N-bromosuccinimide to produce a red-violet colored product with a maximum absorbance of 537nm. For 12 hours the product remains stable. The a molar absorptivity of 0.55x104 L.mole −1.cm-1, Beer's law is followed over a concentration range of 5-100 μg ml-1. Various experimental parameters that influence the development and stability of the generated color output were thoroughly researched and optimization , and a reaction pathway proposal was offered. The proposed approach was successfully used to determine triflouperazine hydrochloride in tablets. |
| doi_str_mv | 10.1063/5.0136254 |
| format | Conference Proceeding |
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The method employs an oxidative coupling reaction with sulfanilic acid in the presence of N-bromosuccinimide to produce a red-violet colored product with a maximum absorbance of 537nm. For 12 hours the product remains stable. The a molar absorptivity of 0.55x104 L.mole −1.cm-1, Beer's law is followed over a concentration range of 5-100 μg ml-1. Various experimental parameters that influence the development and stability of the generated color output were thoroughly researched and optimization , and a reaction pathway proposal was offered. 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The method employs an oxidative coupling reaction with sulfanilic acid in the presence of N-bromosuccinimide to produce a red-violet colored product with a maximum absorbance of 537nm. For 12 hours the product remains stable. The a molar absorptivity of 0.55x104 L.mole −1.cm-1, Beer's law is followed over a concentration range of 5-100 μg ml-1. Various experimental parameters that influence the development and stability of the generated color output were thoroughly researched and optimization , and a reaction pathway proposal was offered. The proposed approach was successfully used to determine triflouperazine hydrochloride in tablets.</description><subject>Absorptivity</subject><subject>Coupling</subject><subject>Optimization</subject><subject>Spectrophotometry</subject><issn>0094-243X</issn><issn>1551-7616</issn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2023</creationdate><recordtype>conference_proceeding</recordtype><recordid>eNp9kEtLxDAUhYMoOD4W_oOAO6FjXm2apYxPGHCj4K6kya0TaZuYtIPjzn9udQbcubpw-fgO5yB0RsmckoJf5nNCecFysYdmNM9pJgta7KMZIUpkTPCXQ3SU0hshTElZztDXNayh9aGDfsApgBmiDys_-A6G6Ay2MEDsXK8H53vsGzx9m3b0AaL-dD3g1cZGb1atj84Cdj22PulXwI2PXcL1Bo8JLPYfzk6KNWDjx9C6_hVH0OZHeoIOGt0mON3dY_R8e_O0uM-Wj3cPi6tlFhjhIqMamlwaUqqyNoQbqUTOJCUMak4KNdWrlSqkkEKYRpdWiFKRmimr6pJobvgxOt96Q_TvI6ShevNj7KfIikmlSskEYxN1saWSccNv6SpE1-m4qSipfiau8mo38X_w2sc_sAq24d9Y0H-Y</recordid><startdate>20230412</startdate><enddate>20230412</enddate><creator>Hussein, Ali M.</creator><creator>Othman, Nebbel S.</creator><general>American Institute of Physics</general><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope></search><sort><creationdate>20230412</creationdate><title>Development spectrophotometric determination of trifluoperazine hydrochloride in dosage forms by used oxidative coupling reaction</title><author>Hussein, Ali M. ; Othman, Nebbel S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2034-1aef57c0898bc03c794527102eb3069094b99674744cfa8d44890b29d9b80a3c3</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Absorptivity</topic><topic>Coupling</topic><topic>Optimization</topic><topic>Spectrophotometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hussein, Ali M.</creatorcontrib><creatorcontrib>Othman, Nebbel S.</creatorcontrib><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hussein, Ali M.</au><au>Othman, Nebbel S.</au><au>Al-Shamani, Ali Najah</au><au>Abid, Dhurgham Hassan</au><au>Wadday, Ahmed Ghanim</au><au>Ibadi, Atheer Kadhim</au><au>Alsaffar, Marwa Fadhil</au><au>Jaaz, Hussein Abad Gazi</au><au>Ali, Faris Mohammed</au><au>AL-Hasnawi, Dhafer Manea Hachim</au><au>Al-Manea, Ahmed Razzaq Hasan</au><au>Alsultani, Saadia H Kadhim</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Development spectrophotometric determination of trifluoperazine hydrochloride in dosage forms by used oxidative coupling reaction</atitle><btitle>AIP conference proceedings</btitle><date>2023-04-12</date><risdate>2023</risdate><volume>2776</volume><issue>1</issue><issn>0094-243X</issn><eissn>1551-7616</eissn><coden>APCPCS</coden><abstract>The determination of triflouperazine hydrochloride in pure and dose forms has been developed using a simple spectrophotometric approach. The method employs an oxidative coupling reaction with sulfanilic acid in the presence of N-bromosuccinimide to produce a red-violet colored product with a maximum absorbance of 537nm. For 12 hours the product remains stable. The a molar absorptivity of 0.55x104 L.mole −1.cm-1, Beer's law is followed over a concentration range of 5-100 μg ml-1. Various experimental parameters that influence the development and stability of the generated color output were thoroughly researched and optimization , and a reaction pathway proposal was offered. The proposed approach was successfully used to determine triflouperazine hydrochloride in tablets.</abstract><cop>Melville</cop><pub>American Institute of Physics</pub><doi>10.1063/5.0136254</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0094-243X |
| ispartof | AIP conference proceedings, 2023, Vol.2776 (1) |
| issn | 0094-243X 1551-7616 |
| language | eng |
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| source | AIP Journals Complete |
| subjects | Absorptivity Coupling Optimization Spectrophotometry |
| title | Development spectrophotometric determination of trifluoperazine hydrochloride in dosage forms by used oxidative coupling reaction |
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