The therapeutic effect of Salvia spinosa on diabetic neuropathy induced by STZ via attenuation of the oxidative pathway
Diabetic peripheral neuropathy (DPN) affects half of diabetic patients with complicated etiologies, in their lifetime. Despite glycemic control, these consequences occur. To date, medical interventions are inconsistent in DN treatment. The purpose of our study is to investigate the neuroprotective e...
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| Veröffentlicht in: | Comparative clinical pathology 2023-04, Vol.32 (2), p.201-209 |
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| creator | Motavallian, Azadeh Yousefbeyk, Fatemeh Shoormeij, Amirhossein Jeshan, Milad Rahmati, Hiva Evazalipour, Mehdi Zamani, Ehsan |
| description | Diabetic peripheral neuropathy (DPN) affects half of diabetic patients with complicated etiologies, in their lifetime. Despite glycemic control, these consequences occur. To date, medical interventions are inconsistent in DN treatment. The purpose of our study is to investigate the neuroprotective effects of
Salvia spinosa
in diabetes-induced mice. After the preparation of the methanolic extract of
S. spinosa
, the antioxidant properties were evaluated by DPPH free radical scavenger assay and phosphomolybdenum reduction assay (PRA). Our study includes six groups of mice (
n
= 5): control, diabetic, and treatment groups (received 50 mg/kg, 100 mg/kg, and 200 mg/kg of methanolic extract of
S. spinosa
). Body weight and blood glucose (FBS) were assessed before the induction of diabetes and subsequently after treatment. DN was evaluated by using hot plate and tail flick tests. Finally, all animals were euthanized and brain tissues were used for the assessment of oxidative stress parameters. Our results showed that FBS levels ameliorated in the
S. spinosa
-treated groups compared to diabetic mice. Early hyperalgesia and late hypoalgesia were shown in diabetic mice and the treatment with
S. spinosa
significantly improved them. the antioxidant effect of
S. spinosa
(DPPH IC
50
: 83 μg/mL, antioxidant capacity in phosphomolybdenum reduction assay (PRA): 270.79 mg αTE/g extract) amended the oxidative stress damages (lipid peroxidation and glutathione oxidation) induced in diabetic mice. This study emphasized the reliable neuroprotective properties of
S. spinosa
in DN due to its antioxidative properties. |
| doi_str_mv | 10.1007/s00580-022-03426-1 |
| format | Article |
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Salvia spinosa
in diabetes-induced mice. After the preparation of the methanolic extract of
S. spinosa
, the antioxidant properties were evaluated by DPPH free radical scavenger assay and phosphomolybdenum reduction assay (PRA). Our study includes six groups of mice (
n
= 5): control, diabetic, and treatment groups (received 50 mg/kg, 100 mg/kg, and 200 mg/kg of methanolic extract of
S. spinosa
). Body weight and blood glucose (FBS) were assessed before the induction of diabetes and subsequently after treatment. DN was evaluated by using hot plate and tail flick tests. Finally, all animals were euthanized and brain tissues were used for the assessment of oxidative stress parameters. Our results showed that FBS levels ameliorated in the
S. spinosa
-treated groups compared to diabetic mice. Early hyperalgesia and late hypoalgesia were shown in diabetic mice and the treatment with
S. spinosa
significantly improved them. the antioxidant effect of
S. spinosa
(DPPH IC
50
: 83 μg/mL, antioxidant capacity in phosphomolybdenum reduction assay (PRA): 270.79 mg αTE/g extract) amended the oxidative stress damages (lipid peroxidation and glutathione oxidation) induced in diabetic mice. This study emphasized the reliable neuroprotective properties of
S. spinosa
in DN due to its antioxidative properties.</description><identifier>ISSN: 1618-565X</identifier><identifier>ISSN: 1618-5641</identifier><identifier>EISSN: 1618-565X</identifier><identifier>DOI: 10.1007/s00580-022-03426-1</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Antioxidants ; Body weight ; Diabetes ; Diabetes mellitus ; Diabetic neuropathy ; Glutathione ; Hematology ; Lipid peroxidation ; Medicine ; Medicine & Public Health ; Neuroprotection ; Oncology ; Original Article ; Oxidative stress ; Pain perception ; Pathology ; Peripheral neuropathy</subject><ispartof>Comparative clinical pathology, 2023-04, Vol.32 (2), p.201-209</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1851-de1f895320c2863e471616acbcd155c736f0be8a9b9b74c176676af4ea819b433</cites><orcidid>0000-0003-2033-0683</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00580-022-03426-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00580-022-03426-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Motavallian, Azadeh</creatorcontrib><creatorcontrib>Yousefbeyk, Fatemeh</creatorcontrib><creatorcontrib>Shoormeij, Amirhossein</creatorcontrib><creatorcontrib>Jeshan, Milad</creatorcontrib><creatorcontrib>Rahmati, Hiva</creatorcontrib><creatorcontrib>Evazalipour, Mehdi</creatorcontrib><creatorcontrib>Zamani, Ehsan</creatorcontrib><title>The therapeutic effect of Salvia spinosa on diabetic neuropathy induced by STZ via attenuation of the oxidative pathway</title><title>Comparative clinical pathology</title><addtitle>Comp Clin Pathol</addtitle><description>Diabetic peripheral neuropathy (DPN) affects half of diabetic patients with complicated etiologies, in their lifetime. Despite glycemic control, these consequences occur. To date, medical interventions are inconsistent in DN treatment. The purpose of our study is to investigate the neuroprotective effects of
Salvia spinosa
in diabetes-induced mice. After the preparation of the methanolic extract of
S. spinosa
, the antioxidant properties were evaluated by DPPH free radical scavenger assay and phosphomolybdenum reduction assay (PRA). Our study includes six groups of mice (
n
= 5): control, diabetic, and treatment groups (received 50 mg/kg, 100 mg/kg, and 200 mg/kg of methanolic extract of
S. spinosa
). Body weight and blood glucose (FBS) were assessed before the induction of diabetes and subsequently after treatment. DN was evaluated by using hot plate and tail flick tests. Finally, all animals were euthanized and brain tissues were used for the assessment of oxidative stress parameters. Our results showed that FBS levels ameliorated in the
S. spinosa
-treated groups compared to diabetic mice. Early hyperalgesia and late hypoalgesia were shown in diabetic mice and the treatment with
S. spinosa
significantly improved them. the antioxidant effect of
S. spinosa
(DPPH IC
50
: 83 μg/mL, antioxidant capacity in phosphomolybdenum reduction assay (PRA): 270.79 mg αTE/g extract) amended the oxidative stress damages (lipid peroxidation and glutathione oxidation) induced in diabetic mice. This study emphasized the reliable neuroprotective properties of
S. spinosa
in DN due to its antioxidative properties.</description><subject>Antioxidants</subject><subject>Body weight</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetic neuropathy</subject><subject>Glutathione</subject><subject>Hematology</subject><subject>Lipid peroxidation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuroprotection</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Oxidative stress</subject><subject>Pain perception</subject><subject>Pathology</subject><subject>Peripheral neuropathy</subject><issn>1618-565X</issn><issn>1618-5641</issn><issn>1618-565X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE1LxDAURYsoOI7-AVcB19V8NGm7lMEvEFzMCOImpOmL02FsapLO2H9vagVducojnHMf7ybJOcGXBOP8ymPMC5xiSlPMMipScpDMiCBFygV_OfwzHycn3m8wJrxgbJbsV2tAYQ1OddCHRiMwBnRA1qCl2u4ahXzXtNYrZFtUN6qCEWqhd7ZTYT2gpq17DTWqBrRcvaLRUCFA26vQRCXmxHRkP5s6fuwAjdZeDafJkVFbD2c_7zx5vr1ZLe7Tx6e7h8X1Y6pJwUlaAzFFyRnFmhaCQZbHQ4TSla4J5zpnwuAKClVWZZVnmuRC5EKZDFRByipjbJ5cTLmdsx89-CA3tndtXClpXjLKWS5opOhEaWe9d2Bk55p35QZJsBwLllPBMhYsvwuWJEpsknyE2zdwv9H_WF_YN39G</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Motavallian, Azadeh</creator><creator>Yousefbeyk, Fatemeh</creator><creator>Shoormeij, Amirhossein</creator><creator>Jeshan, Milad</creator><creator>Rahmati, Hiva</creator><creator>Evazalipour, Mehdi</creator><creator>Zamani, Ehsan</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0003-2033-0683</orcidid></search><sort><creationdate>20230401</creationdate><title>The therapeutic effect of Salvia spinosa on diabetic neuropathy induced by STZ via attenuation of the oxidative pathway</title><author>Motavallian, Azadeh ; Yousefbeyk, Fatemeh ; Shoormeij, Amirhossein ; Jeshan, Milad ; Rahmati, Hiva ; Evazalipour, Mehdi ; Zamani, Ehsan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1851-de1f895320c2863e471616acbcd155c736f0be8a9b9b74c176676af4ea819b433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antioxidants</topic><topic>Body weight</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetic neuropathy</topic><topic>Glutathione</topic><topic>Hematology</topic><topic>Lipid peroxidation</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuroprotection</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Oxidative stress</topic><topic>Pain perception</topic><topic>Pathology</topic><topic>Peripheral neuropathy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Motavallian, Azadeh</creatorcontrib><creatorcontrib>Yousefbeyk, Fatemeh</creatorcontrib><creatorcontrib>Shoormeij, Amirhossein</creatorcontrib><creatorcontrib>Jeshan, Milad</creatorcontrib><creatorcontrib>Rahmati, Hiva</creatorcontrib><creatorcontrib>Evazalipour, Mehdi</creatorcontrib><creatorcontrib>Zamani, Ehsan</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Comparative clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Motavallian, Azadeh</au><au>Yousefbeyk, Fatemeh</au><au>Shoormeij, Amirhossein</au><au>Jeshan, Milad</au><au>Rahmati, Hiva</au><au>Evazalipour, Mehdi</au><au>Zamani, Ehsan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The therapeutic effect of Salvia spinosa on diabetic neuropathy induced by STZ via attenuation of the oxidative pathway</atitle><jtitle>Comparative clinical pathology</jtitle><stitle>Comp Clin Pathol</stitle><date>2023-04-01</date><risdate>2023</risdate><volume>32</volume><issue>2</issue><spage>201</spage><epage>209</epage><pages>201-209</pages><issn>1618-565X</issn><issn>1618-5641</issn><eissn>1618-565X</eissn><abstract>Diabetic peripheral neuropathy (DPN) affects half of diabetic patients with complicated etiologies, in their lifetime. Despite glycemic control, these consequences occur. To date, medical interventions are inconsistent in DN treatment. The purpose of our study is to investigate the neuroprotective effects of
Salvia spinosa
in diabetes-induced mice. After the preparation of the methanolic extract of
S. spinosa
, the antioxidant properties were evaluated by DPPH free radical scavenger assay and phosphomolybdenum reduction assay (PRA). Our study includes six groups of mice (
n
= 5): control, diabetic, and treatment groups (received 50 mg/kg, 100 mg/kg, and 200 mg/kg of methanolic extract of
S. spinosa
). Body weight and blood glucose (FBS) were assessed before the induction of diabetes and subsequently after treatment. DN was evaluated by using hot plate and tail flick tests. Finally, all animals were euthanized and brain tissues were used for the assessment of oxidative stress parameters. Our results showed that FBS levels ameliorated in the
S. spinosa
-treated groups compared to diabetic mice. Early hyperalgesia and late hypoalgesia were shown in diabetic mice and the treatment with
S. spinosa
significantly improved them. the antioxidant effect of
S. spinosa
(DPPH IC
50
: 83 μg/mL, antioxidant capacity in phosphomolybdenum reduction assay (PRA): 270.79 mg αTE/g extract) amended the oxidative stress damages (lipid peroxidation and glutathione oxidation) induced in diabetic mice. This study emphasized the reliable neuroprotective properties of
S. spinosa
in DN due to its antioxidative properties.</abstract><cop>London</cop><pub>Springer London</pub><doi>10.1007/s00580-022-03426-1</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2033-0683</orcidid></addata></record> |
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| source | SpringerNature Journals |
| subjects | Antioxidants Body weight Diabetes Diabetes mellitus Diabetic neuropathy Glutathione Hematology Lipid peroxidation Medicine Medicine & Public Health Neuroprotection Oncology Original Article Oxidative stress Pain perception Pathology Peripheral neuropathy |
| title | The therapeutic effect of Salvia spinosa on diabetic neuropathy induced by STZ via attenuation of the oxidative pathway |
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