Frontispiece: Activity Sensing of Coagulation and Fibrinolytic Proteases

Frontispiece: Activity Sensing of Coagulation and Fibrinolytic Proteases

This work describes the main proteases present in the coagulation cascade and fibrinolytic processes and highlights existing strategies of sensing these diagnostic targets. An overview of endogenous substrates and synthetic peptide probes is given in order to contribute to the challenges ahead in co...

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Veröffentlicht in:Chemistry : a European journal 2023-03, Vol.29 (18), p.n/a
Hauptverfasser: Sondag, Daan, Verhoeven, Stijn, Löwik, Dennis W. P. M., Geffen, Mark, Veer, Cornelis van't, Heerde, Waander L., Boltje, Thomas J., Rutjes, Floris P. J. T.
Format: Artikel
Sprache:eng
Schlagworte:
activity sensing
blood coagulation
Chemistry
Coagulation
Fibrin
peptide probes
protease inhibition
serine proteases
Substrates
thrombosis
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Beschreibung
Zusammenfassung:This work describes the main proteases present in the coagulation cascade and fibrinolytic processes and highlights existing strategies of sensing these diagnostic targets. An overview of endogenous substrates and synthetic peptide probes is given in order to contribute to the challenges ahead in coagulation and fibrinolytic monitoring. For more details, see the Review by W.L. van Heerde, T.J. Boltje, F.P.J.T. Rutjes, et al. (DOI: 10.1002/chem.202203473).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202381862