Synthesis of New Cyclohexenone Derivatives Using Potassium Phthalimide as a Green Organocatalyst. One-Pot Microwave-Assisted Synthesis and Antimicrobial Evaluation

A direct one-pot three-component reaction of 4-acetyl- N -benzylbenzamide, ethyl acetoacetate or methyl acetoacetate, and aromatic aldehydes under microwave irradiation afforded a series of new cyclo­hexenone derivatives. The proposed procedure has the advantages of one-pot reaction, high efficiency, short reaction time, and simple workup. The antimicrobial activity of the obtained cyclohexenone derivatives was tested against a variety of bacteria ( E. coli , S. aureus , S. pyogenes , P. aeruginosa ) and fungi ( C. albicans , A. niger , A. clavatus ).