Synthesis, characterization, biological screening and determination of stability constants of N,N′-Bis[1-(4-chlorophenyl)ethylidene]ethane-1,2-diamine
A Schiff base ligand, N , N ′-bis[1-(4-chlorophenyl)ethylidene]ethane-1,2-diamine ( SBL ), was synthesized by condensation of 4-chloroacetophenone with ethylenediamine in methanol in the presence of H 2 SO 4 as catalyst. The structure of SBL was elucidated by spectroscopic ( 1 H-NMR, 13 C-NMR, IR an...
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Veröffentlicht in: | SN applied sciences 2021, Vol.3 (1), p.22, Article 22 |
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Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
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Zusammenfassung: | A Schiff base ligand,
N
,
N
′-bis[1-(4-chlorophenyl)ethylidene]ethane-1,2-diamine (
SBL
), was synthesized by condensation of 4-chloroacetophenone with ethylenediamine in methanol in the presence of H
2
SO
4
as catalyst. The structure of
SBL
was elucidated by spectroscopic (
1
H-NMR,
13
C-NMR, IR and MS) and elemental analyses, and also confirmed by XRD. The
SBL
was used to prepare metal complexes
1-2
with Pb
+2
and Cd
+2
, respectively. The structures of the complexes were elucidated by IR, MS and elemental analyses. On the basis of electronic spectra and magnetic moment data, octahedral geometry was proposed for the synthesized complexes
1-2
. The conductivity data showed the non-electrolytic nature of the complexes
1-2
. The
SBL
and complexes
1-2
were subjected to measure their biological potential against
Staphylococcus aureus, Bacillus subtilis
and
Escherichia coli
bacteria.
SBL
showed non-significant anti-bacterial potential whereas complexes showed moderate potential as compared to standard impinium. In the toxicity with brine shrimp larvae, complexes showed more toxic effect than the
SBL
. In the experiments to determine the stability constants of
SBL
with CuCl
2
, Cu(OAc)
2
, CoCl
2
and Co(NO
3
)
2
;
SBL
showed highest stability constants with Cu(OAc)
2
which is 1.550 × 10
7
at 1:1 (L:M) and second highest with Co(NO
3
)
2
which is 6.861 × 10
6
at 3:2 (L:M). |
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ISSN: | 2523-3963 2523-3971 |
DOI: | 10.1007/s42452-020-04029-7 |