Serum Electrolyte Values and Blood Oxidative Stress Parameters in Patients with Focal and Generalized Epilepsy

Because epilepsy pathogenesis is affected by serum minerals and antioxidant enzymes, this study was designed to evaluate whether there was a relationship among electrolytes (Na, Ca, K, Cl, P, Mg), trace elements (Fe, Zn, Cu) and oxidative stress in patients with generalized or focal epilepsy. Twenty healthy individuals (control group), and 20 focal and 20 generalized epilepsy patients (patient groups) were included in the study. Control and patient groups were matched with age (30-40 years old), body mass index (25 -28) and sex (10 males and 10 females). Serum Na, Ca, K, Cl, P, Mg and Fe levels were analyzed in an autoanalyzer, serum Zn and Cu were analyzed in a mass spectrophotometer, total antioxidant status, total oxidant status and myeloperoxidase levels were measured spectrophotometrically. The oxidative stress index increased (p