Enhanced healing of skin wounds in ischemic rabbits using chitosan/hyaluronan/edaravone composite membranes: effects of laponite, carbon and silver-plated carbon nanofiber fillers
We examined the free-radical scavenging capacity of edaravone using the standard spectroscopic methods. Further, the impact of wound dressings composed of chitosan/hyaluronan with the addition of H atom and/or electron donoring edaravone in the absence and presence of laponite, C-nanofibers or silve...
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| Veröffentlicht in: | Chemical papers 2023-04, Vol.77 (4), p.1835-1841 |
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| creator | Valachová, Katarína Švík, Karol Jurčík, Rastislav Ondruška, Ľubomír Biró, Csaba Šoltés, Ladislav |
| description | We examined the free-radical scavenging capacity of edaravone using the standard spectroscopic methods. Further, the impact of wound dressings composed of chitosan/hyaluronan with the addition of H atom and/or electron donoring edaravone in the absence and presence of laponite, C-nanofibers or silver-plated C-nanofibers was assessed on the healing of skin lacerations in ischemic ears of rabbits. The skin wound healing was compared with the untreated animals and animals, in which the wound was protected by a bicomponent chitosan/hyaluronan membranes. The in vitro results showed that edaravone in a dose-dependent manner was both free electron and H atom donor. The results of in vivo experiments showed that the addition of edaravone into chitosan/hyaluronan resulted in faster healing of skin wounds in ischemic rabbits. As proved also by histological investigation, the incorporation of laponite, C-nanofibers or silver-plated C-nanofibers into the composite membranes had significantly beneficial effects on skin wound healing. |
| doi_str_mv | 10.1007/s11696-022-02553-x |
| format | Article |
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Further, the impact of wound dressings composed of chitosan/hyaluronan with the addition of H atom and/or electron donoring edaravone in the absence and presence of laponite, C-nanofibers or silver-plated C-nanofibers was assessed on the healing of skin lacerations in ischemic ears of rabbits. The skin wound healing was compared with the untreated animals and animals, in which the wound was protected by a bicomponent chitosan/hyaluronan membranes. The in vitro results showed that edaravone in a dose-dependent manner was both free electron and H atom donor. The results of in vivo experiments showed that the addition of edaravone into chitosan/hyaluronan resulted in faster healing of skin wounds in ischemic rabbits. As proved also by histological investigation, the incorporation of laponite, C-nanofibers or silver-plated C-nanofibers into the composite membranes had significantly beneficial effects on skin wound healing.</description><identifier>ISSN: 0366-6352</identifier><identifier>EISSN: 1336-9075</identifier><identifier>EISSN: 2585-7290</identifier><identifier>DOI: 10.1007/s11696-022-02553-x</identifier><language>eng</language><publisher>Warsaw: Versita</publisher><subject>Animals ; Biochemistry ; Biotechnology ; Carbon fibers ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Chitosan ; Free electrons ; Hyaluronic acid ; Industrial Chemistry/Chemical Engineering ; Materials Science ; Medicinal Chemistry ; Membranes ; Nanofibers ; Original Paper ; Rabbits ; Scavenging ; Silver plating ; Wound healing</subject><ispartof>Chemical papers, 2023-04, Vol.77 (4), p.1835-1841</ispartof><rights>Institute of Chemistry, Slovak Academy of Sciences 2022. 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Pap</addtitle><description>We examined the free-radical scavenging capacity of edaravone using the standard spectroscopic methods. Further, the impact of wound dressings composed of chitosan/hyaluronan with the addition of H atom and/or electron donoring edaravone in the absence and presence of laponite, C-nanofibers or silver-plated C-nanofibers was assessed on the healing of skin lacerations in ischemic ears of rabbits. The skin wound healing was compared with the untreated animals and animals, in which the wound was protected by a bicomponent chitosan/hyaluronan membranes. The in vitro results showed that edaravone in a dose-dependent manner was both free electron and H atom donor. The results of in vivo experiments showed that the addition of edaravone into chitosan/hyaluronan resulted in faster healing of skin wounds in ischemic rabbits. As proved also by histological investigation, the incorporation of laponite, C-nanofibers or silver-plated C-nanofibers into the composite membranes had significantly beneficial effects on skin wound healing.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biotechnology</subject><subject>Carbon fibers</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Chitosan</subject><subject>Free electrons</subject><subject>Hyaluronic acid</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Materials Science</subject><subject>Medicinal Chemistry</subject><subject>Membranes</subject><subject>Nanofibers</subject><subject>Original Paper</subject><subject>Rabbits</subject><subject>Scavenging</subject><subject>Silver plating</subject><subject>Wound healing</subject><issn>0366-6352</issn><issn>1336-9075</issn><issn>2585-7290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9Uctu1TAQtRCVuJT-ACtLbAn149q5YYeq8pAqsaFra2yPG5fEDnZS2u_qD-JyK7FjMZqRzmukQ8hbzj5wxvrzyrkedMeEaKOU7O5fkB2XUncD69VLsmNS605LJV6R17XeMrbfM8V25PEyjZAcejoiTDHd0Bxo_RkT_Z235CttV6xuxDk6WsDauFa61SeiG-OaK6Tz8QGmreTUTvRQ4C4npC7PS65xRTrjbAskrB8phoCuGbSMCZacGvyeOig2JwrJ0xqnOyzdMsHaPnoGmm8O0WKhIU4TlvqGnASYKp4971Ny_fnyx8XX7ur7l28Xn646J_mwdhwtIijFJdeh98KD1oFLFvDAg5BeDDbwgMh7NYCzg-ZSHXovBfjBAmp5St4dfZeSf21YV3Obt5JapBH9QQ_yoIZ9Y4kjy5Vca8FglhJnKA-GM_NUjjmWY1o55m855r6J5FFUGzndYPln_R_VH9--mGA</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Valachová, Katarína</creator><creator>Švík, Karol</creator><creator>Jurčík, Rastislav</creator><creator>Ondruška, Ľubomír</creator><creator>Biró, Csaba</creator><creator>Šoltés, Ladislav</creator><general>Versita</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20230401</creationdate><title>Enhanced healing of skin wounds in ischemic rabbits using chitosan/hyaluronan/edaravone composite membranes: effects of laponite, carbon and silver-plated carbon nanofiber fillers</title><author>Valachová, Katarína ; Švík, Karol ; Jurčík, Rastislav ; Ondruška, Ľubomír ; Biró, Csaba ; Šoltés, Ladislav</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-1ebeea551316f7d2da66f130fe81f23d29bf1fee1759acb9613587d32ad9bae63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Biotechnology</topic><topic>Carbon fibers</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Chitosan</topic><topic>Free electrons</topic><topic>Hyaluronic acid</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Materials Science</topic><topic>Medicinal Chemistry</topic><topic>Membranes</topic><topic>Nanofibers</topic><topic>Original Paper</topic><topic>Rabbits</topic><topic>Scavenging</topic><topic>Silver plating</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Valachová, Katarína</creatorcontrib><creatorcontrib>Švík, Karol</creatorcontrib><creatorcontrib>Jurčík, Rastislav</creatorcontrib><creatorcontrib>Ondruška, Ľubomír</creatorcontrib><creatorcontrib>Biró, Csaba</creatorcontrib><creatorcontrib>Šoltés, Ladislav</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical papers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Valachová, Katarína</au><au>Švík, Karol</au><au>Jurčík, Rastislav</au><au>Ondruška, Ľubomír</au><au>Biró, Csaba</au><au>Šoltés, Ladislav</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced healing of skin wounds in ischemic rabbits using chitosan/hyaluronan/edaravone composite membranes: effects of laponite, carbon and silver-plated carbon nanofiber fillers</atitle><jtitle>Chemical papers</jtitle><stitle>Chem. 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| subjects | Animals Biochemistry Biotechnology Carbon fibers Chemistry Chemistry and Materials Science Chemistry/Food Science Chitosan Free electrons Hyaluronic acid Industrial Chemistry/Chemical Engineering Materials Science Medicinal Chemistry Membranes Nanofibers Original Paper Rabbits Scavenging Silver plating Wound healing |
| title | Enhanced healing of skin wounds in ischemic rabbits using chitosan/hyaluronan/edaravone composite membranes: effects of laponite, carbon and silver-plated carbon nanofiber fillers |
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