New O-superfamily conotoxins fromConus striatus inhabited near Chinese Hainan Island

Conotoxins are short peptide-toxins with specific targets and large diversity. They are useful in analgesia, neuroprotection, detection of some kinds of deseases, and receptor and ion channel study. In order to explore the conotoxin resourses of Chinese oceans, rapid amplification of 3′ cDNA ends (R...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chinese science bulletin 2000-03, Vol.45 (5), p.432-435
Hauptverfasser:	Lu, Baisong, Yu, Fang, Wang, Jianhua, Zhao, Siqing, Zhao, Dong, Dai, Qiuyun, Huang, Peitang, Huang, Cuifen
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Calcium antagonists Calcium channel blockers Calcium channels Calcium channels (N-type) Conotoxins Ion channels Neuroprotection Oceans Toxins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Conotoxins are short peptide-toxins with specific targets and large diversity. They are useful in analgesia, neuroprotection, detection of some kinds of deseases, and receptor and ion channel study. In order to explore the conotoxin resourses of Chinese oceans, rapid amplification of 3′ cDNA ends (RACE) method was utilized to systemically analyze the O-superfamily conotoxin content ofConus striatus inhabited near Chinese Hainan Island. Six new O-superfamily conopeptides were identified, one of which is highly homologous to MVIIA, an N-type calcium channel antagonist.
ISSN:	1001-6538 2095-9273 1861-9541 2095-9281
DOI:	10.1007/BF02884945