Radiological Features of Osteogenesis Imperfecta Type V: a Report of Two Cases

Osteogenesis imperfecta type V is a rare subtype of osteogenesis imperfecta with unique clinical, radiological, and histological features. Herein, we report two paediatric patients with osteogenesis imperfecta type V, both presenting with recurrent bone fractures since early childhood and the classical radiological features of osteogenesis imperfecta type V (calcified radio-ulnar interosseous membrane). One of them also developed hypertrophic callus formation. Knowledge and recognition of these specific radiographic findings can facilitate a timely diagnosis of osteogenesis imperfecta type V, which may have significant implications on management. Such consideration includes bisphosphonate use (a well-established treatment for certain disease subtypes of osteogenesis imperfecta), but may lead to progression of hypertrophic callus in osteogenesis imperfecta type V.