Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing
Error-corrected next-generation sequencing (ecNGS) is an emerging technology with the potential to revolutionize the field of genetic toxicology. Here, we present recommendations from an expert working group convened to discuss potential applications, advantages and challenges associated with implem...
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| Veröffentlicht in: | Nature reviews. Drug discovery 2023-03, Vol.22 (3), p.165-166 |
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| container_title | Nature reviews. Drug discovery |
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| creator | Marchetti, Francesco Cardoso, Renato Chen, Connie L. Douglas, George R. Elloway, Joanne Escobar, Patricia A. Harper Jr, Tod Heflich, Robert H. Kidd, Darren Lynch, Anthony M. Myers, Meagan B. Parsons, Barbara L. Salk, Jesse J. Settivari, Raja S. Smith-Roe, Stephanie L. Witt, Kristine L. Yauk, Carole Young, Robert R. Zhang, Shaofei Minocherhomji, Sheroy |
| description | Error-corrected next-generation sequencing (ecNGS) is an emerging technology with the potential to revolutionize the field of genetic toxicology. Here, we present recommendations from an expert working group convened to discuss potential applications, advantages and challenges associated with implementing ecNGS in nonclinical safety studies.
Error-corrected next-generation sequencing (ecNGS) is an emerging technology with the potential to revolutionize the field of genetic toxicology. Here, we present recommendations from an expert working group convened to discuss potential applications, advantages and challenges associated with implementing ecNGS in nonclinical safety studies. |
| doi_str_mv | 10.1038/d41573-023-00014-y |
| format | Article |
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Error-corrected next-generation sequencing (ecNGS) is an emerging technology with the potential to revolutionize the field of genetic toxicology. Here, we present recommendations from an expert working group convened to discuss potential applications, advantages and challenges associated with implementing ecNGS in nonclinical safety studies.</description><identifier>ISSN: 1474-1776</identifier><identifier>EISSN: 1474-1784</identifier><identifier>DOI: 10.1038/d41573-023-00014-y</identifier><identifier>PMID: 36646809</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Biomedicine ; Biotechnology ; Cancer Research ; Carcinogenicity Tests ; Comment ; DNA Damage ; High-Throughput Nucleotide Sequencing ; Humans ; Medicinal Chemistry ; Molecular Medicine ; Pharmacology/Toxicology</subject><ispartof>Nature reviews. Drug discovery, 2023-03, Vol.22 (3), p.165-166</ispartof><rights>Springer Nature Limited 2023</rights><rights>Springer Nature Limited 2023.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-101cf9eb21bb1121092145567f6e970e4493853413a355742c85dcaa0d5c166f3</citedby><cites>FETCH-LOGICAL-c375t-101cf9eb21bb1121092145567f6e970e4493853413a355742c85dcaa0d5c166f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/d41573-023-00014-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/d41573-023-00014-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36646809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marchetti, Francesco</creatorcontrib><creatorcontrib>Cardoso, Renato</creatorcontrib><creatorcontrib>Chen, Connie L.</creatorcontrib><creatorcontrib>Douglas, George R.</creatorcontrib><creatorcontrib>Elloway, Joanne</creatorcontrib><creatorcontrib>Escobar, Patricia A.</creatorcontrib><creatorcontrib>Harper Jr, Tod</creatorcontrib><creatorcontrib>Heflich, Robert H.</creatorcontrib><creatorcontrib>Kidd, Darren</creatorcontrib><creatorcontrib>Lynch, Anthony M.</creatorcontrib><creatorcontrib>Myers, Meagan B.</creatorcontrib><creatorcontrib>Parsons, Barbara L.</creatorcontrib><creatorcontrib>Salk, Jesse J.</creatorcontrib><creatorcontrib>Settivari, Raja S.</creatorcontrib><creatorcontrib>Smith-Roe, Stephanie L.</creatorcontrib><creatorcontrib>Witt, Kristine L.</creatorcontrib><creatorcontrib>Yauk, Carole</creatorcontrib><creatorcontrib>Young, Robert R.</creatorcontrib><creatorcontrib>Zhang, Shaofei</creatorcontrib><creatorcontrib>Minocherhomji, Sheroy</creatorcontrib><title>Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing</title><title>Nature reviews. Drug discovery</title><addtitle>Nat Rev Drug Discov</addtitle><addtitle>Nat Rev Drug Discov</addtitle><description>Error-corrected next-generation sequencing (ecNGS) is an emerging technology with the potential to revolutionize the field of genetic toxicology. Here, we present recommendations from an expert working group convened to discuss potential applications, advantages and challenges associated with implementing ecNGS in nonclinical safety studies.
Error-corrected next-generation sequencing (ecNGS) is an emerging technology with the potential to revolutionize the field of genetic toxicology. Here, we present recommendations from an expert working group convened to discuss potential applications, advantages and challenges associated with implementing ecNGS in nonclinical safety studies.</description><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Cancer Research</subject><subject>Carcinogenicity Tests</subject><subject>Comment</subject><subject>DNA Damage</subject><subject>High-Throughput Nucleotide Sequencing</subject><subject>Humans</subject><subject>Medicinal Chemistry</subject><subject>Molecular Medicine</subject><subject>Pharmacology/Toxicology</subject><issn>1474-1776</issn><issn>1474-1784</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kE1LAzEQhoMotlb_gAdZ8LyayefuUUr9gIIXPYc0my1b2qQmqXT_vdGt9eYhTJh53neGF6FrwHeAaXXfMOCSlpjkhzGwsj9BY2CSlSArdnr8SzFCFzGuMiNAknM0okIwUeF6jFazEHwojQ_BmmSbwtl9KpfW2aBT510R7cfOOtO5ZZF8oZtP7YwtnHdm3bnO6HWRYZ_8vjNd6gvtmsLokHmf-0Mv2Ziy_hKdtXod7dWhTtD74-xt-lzOX59epg_z0lDJUwkYTFvbBYHFAoAArgkwzoVsha0ltozVtOKUAdWUc8mIqXhjtMYNNyBESyfodvDdBp9vj0mt_C64vFIRWREsgXOaKTJQJvgYg23VNnQbHXoFWH3Hq4Z4VY5X_cSr-iy6OVjvFhvbHCW_eWaADkDMI7e04W_3P7ZfacCHLg</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Marchetti, Francesco</creator><creator>Cardoso, Renato</creator><creator>Chen, Connie L.</creator><creator>Douglas, George R.</creator><creator>Elloway, Joanne</creator><creator>Escobar, Patricia A.</creator><creator>Harper Jr, Tod</creator><creator>Heflich, Robert H.</creator><creator>Kidd, Darren</creator><creator>Lynch, Anthony M.</creator><creator>Myers, Meagan B.</creator><creator>Parsons, Barbara L.</creator><creator>Salk, Jesse J.</creator><creator>Settivari, Raja S.</creator><creator>Smith-Roe, Stephanie L.</creator><creator>Witt, Kristine L.</creator><creator>Yauk, Carole</creator><creator>Young, Robert R.</creator><creator>Zhang, Shaofei</creator><creator>Minocherhomji, Sheroy</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20230301</creationdate><title>Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing</title><author>Marchetti, Francesco ; 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Drug discovery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marchetti, Francesco</au><au>Cardoso, Renato</au><au>Chen, Connie L.</au><au>Douglas, George R.</au><au>Elloway, Joanne</au><au>Escobar, Patricia A.</au><au>Harper Jr, Tod</au><au>Heflich, Robert H.</au><au>Kidd, Darren</au><au>Lynch, Anthony M.</au><au>Myers, Meagan B.</au><au>Parsons, Barbara L.</au><au>Salk, Jesse J.</au><au>Settivari, Raja S.</au><au>Smith-Roe, Stephanie L.</au><au>Witt, Kristine L.</au><au>Yauk, Carole</au><au>Young, Robert R.</au><au>Zhang, Shaofei</au><au>Minocherhomji, Sheroy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing</atitle><jtitle>Nature reviews. Drug discovery</jtitle><stitle>Nat Rev Drug Discov</stitle><addtitle>Nat Rev Drug Discov</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>22</volume><issue>3</issue><spage>165</spage><epage>166</epage><pages>165-166</pages><issn>1474-1776</issn><eissn>1474-1784</eissn><abstract>Error-corrected next-generation sequencing (ecNGS) is an emerging technology with the potential to revolutionize the field of genetic toxicology. Here, we present recommendations from an expert working group convened to discuss potential applications, advantages and challenges associated with implementing ecNGS in nonclinical safety studies.
Error-corrected next-generation sequencing (ecNGS) is an emerging technology with the potential to revolutionize the field of genetic toxicology. Here, we present recommendations from an expert working group convened to discuss potential applications, advantages and challenges associated with implementing ecNGS in nonclinical safety studies.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>36646809</pmid><doi>10.1038/d41573-023-00014-y</doi><tpages>2</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Biomedicine Biotechnology Cancer Research Carcinogenicity Tests Comment DNA Damage High-Throughput Nucleotide Sequencing Humans Medicinal Chemistry Molecular Medicine Pharmacology/Toxicology |
| title | Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing |
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