Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing

Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing

Error-corrected next-generation sequencing (ecNGS) is an emerging technology with the potential to revolutionize the field of genetic toxicology. Here, we present recommendations from an expert working group convened to discuss potential applications, advantages and challenges associated with implem...

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Veröffentlicht in:Nature reviews. Drug discovery 2023-03, Vol.22 (3), p.165-166
Hauptverfasser: Marchetti, Francesco, Cardoso, Renato, Chen, Connie L., Douglas, George R., Elloway, Joanne, Escobar, Patricia A., Harper Jr, Tod, Heflich, Robert H., Kidd, Darren, Lynch, Anthony M., Myers, Meagan B., Parsons, Barbara L., Salk, Jesse J., Settivari, Raja S., Smith-Roe, Stephanie L., Witt, Kristine L., Yauk, Carole, Young, Robert R., Zhang, Shaofei, Minocherhomji, Sheroy
Format: Artikel
Sprache:eng
Schlagworte:
Biomedicine
Biotechnology
Cancer Research
Carcinogenicity Tests
Comment
DNA Damage
High-Throughput Nucleotide Sequencing
Humans
Medicinal Chemistry
Molecular Medicine
Pharmacology/Toxicology
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Zusammenfassung:Error-corrected next-generation sequencing (ecNGS) is an emerging technology with the potential to revolutionize the field of genetic toxicology. Here, we present recommendations from an expert working group convened to discuss potential applications, advantages and challenges associated with implementing ecNGS in nonclinical safety studies. Error-corrected next-generation sequencing (ecNGS) is an emerging technology with the potential to revolutionize the field of genetic toxicology. Here, we present recommendations from an expert working group convened to discuss potential applications, advantages and challenges associated with implementing ecNGS in nonclinical safety studies.
ISSN:1474-1776
1474-1784
DOI:10.1038/d41573-023-00014-y