Design of a New Coating Agent Based on Graphene Oxide and Antimicrobial/Spermicidal Peptide (Sarcotoxin Pd) for Condom Coating: New Strategy for Prevention of Unplanned Pregnancy and Sexually Transmitted Infections
In this study, sarcotoxin Pd-functionalized graphene oxide (GO-Pd) was synthesized as a new condom-coating agent. Antimicrobial activity was evaluated by radial diffusion assay (RDA) and absorbance-based methods. Sperm motility and morphology were assessed in different concentrations of designed nan...
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Veröffentlicht in: | Journal of nanomaterials 2023, Vol.2023, p.1-9 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | In this study, sarcotoxin Pd-functionalized graphene oxide (GO-Pd) was synthesized as a new condom-coating agent. Antimicrobial activity was evaluated by radial diffusion assay (RDA) and absorbance-based methods. Sperm motility and morphology were assessed in different concentrations of designed nanostructures. Peptide stability on the GO structures was assessed by the CD technique. GO-Pd showed the highest contact angle. The results approved that GO-Pd had broad-spectrum antimicrobial activities against examined pathogens, especially vaginal infections such as Candida vulvovaginitis. This antimicrobial activity was more than pristine peptides, vancomycin, and fluconazole. GO-Pd also had a higher inhibitory activity on the sperm motility and viability than pristine peptides. GO-Pd had high stability and activity in all examined conditions. But, naked peptides had low stability and activity after incubation in acidic pH and high temperatures (>38°C). In all tests, GO-Pd showed a significant difference compared to naked peptide. Based on the results, GO-Pd can be used as a condom coating to prevent unplanned pregnancy and sexually transmitted infections. |
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ISSN: | 1687-4110 1687-4129 |
DOI: | 10.1155/2023/2487468 |