Ultrasound Allied Laser Sono-Photobiomodulation Activated Nano-Curcumin: Up-and-Coming Selective Cancer Cell Killing Modality

The purpose of this study was to assess the effectiveness of activated nano-curcumin as a cancer-targeted therapy. Six groups of albino mice with cancer implants were used for this study. Sono- (ultrasound) and photo- (blue laser) were used as energy sources. The outcomes showed that nano-curcumin is an effective photo-sono sensitizer for the treatment of cancer. Upon activation with blue laser and/or ultrasound, nano-curcumin plays a crucial part in inhibiting tumor development and promoting cancer cell death. Our findings showed that activated nano-curcumin might be used as a natural nanosensitizer for cancer targeted sono-photobiomodulation therapy (SPBMT). Highlights New trend of cancer treatment: sono-photo-biomodulation therapy (SPBMT) in combination with nano-curcumin as a sono-photo-sensitizer. A phytochemical nanomaterial with great potential as effective drug delivery targeting system for SPBMT. Nontoxic, safe, and locally activated cancer treatment modality. Selective cancer killing. Graphical Abstract